Publications by authors named "Colin Tice"

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PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication.
Lori A Emert-Sedlak, Colin M Tice, Haibin Shi, John J Alvarado, Sherry T Shu

Cell Chem Biol· April 2024

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PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication.
Lori A Emert-Sedlak, Colin M Tice, Haibin Shi, John J Alvarado, Sherry T Shu

bioRxiv· September 2023

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Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor.
Lori A Emert-Sedlak, Haibin Shi, Colin M Tice, Li Chen, John J Alvarado

Viruses· September 2022

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Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.
Haibin Shi, Colin M Tice, Lori Emert-Sedlak, Li Chen, Wing Fai Li

ACS Infect Dis· February 2020

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Discovery of Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Using a Novel Growth-Based Protocol of Screening and Optimization in CONTOUR.
Zhijie Liu, Suresh B Singh, Yajun Zheng, Peter Lindblom, Colin Tice

J Chem Inf Model· August 2019

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Conformational control in structure-based drug design.
Yajun Zheng, Colin M Tice, Suresh B Singh

Bioorg Med Chem Lett· July 2017

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.
Linghang Zhuang, Colin M Tice, Zhenrong Xu, Wei Zhao, Salvacion Cacatian

Bioorg Med Chem· July 2017

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Colin M Tice, Paul B Noto, Kristi Yi Fan, Wei Zhao, Stephen D Lotesta

Bioorg Med Chem Lett· October 2016

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The utilization of spirocyclic scaffolds in novel drug discovery.
Ya-Jun Zheng, Colin M Tice

Expert Opin Drug Discov· September 2016

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Non-canonical modulators of nuclear receptors.
Colin M Tice, Ya-Jun Zheng

Bioorg Med Chem Lett· September 2016

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Yajun Zheng, Linghang Zhuang, Kristi Yi Fan, Colin M Tice, Wei Zhao

J Med Chem· April 2016

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The medicinal chemistry of liver X receptor (LXR) modulators.
Colin M Tice, Paul B Noto, Kristi Yi Fan, Linghang Zhuang, Deepak S Lala

J Med Chem· September 2014

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The use of spirocyclic scaffolds in drug discovery.
Yajun Zheng, Colin M Tice, Suresh B Singh

Bioorg Med Chem Lett· August 2014

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Lanqi Jia, Robert D Simpson, Jing Yuan, Zhenrong Xu, Wei Zhao, Colin M Tice

ACS Med Chem Lett· October 2011

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Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
Zhenrong Xu, Colin M Tice, Wei Zhao, Salvacion Cacatian, Yuan-Jie Ye

J Med Chem· September 2011

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Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Jing Yuan, Robert D Simpson, Wei Zhao, Colin M Tice, Zhenrong Xu

Bioorg Med Chem Lett· August 2011

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Structure based design of 11β-HSD1 inhibitors.
Suresh Singh, Colin Tice

Curr Pharm Biotechnol· November 2010

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Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.
Colin M Tice, Wei Zhao, Paula M Krosky, Barbara A Kruk, Jennifer Berbaum

Bioorg Med Chem Lett· November 2010

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Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.
Colin M Tice, Wei Zhao, Zhenrong Xu, Salvacion T Cacatian, Robert D Simpson

Bioorg Med Chem Lett· February 2010

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Optimization of orally bioavailable alkyl amine renin inhibitors.
Zhenrong Xu, Salvacion Cacatian, Jing Yuan, Robert D Simpson, Lanqi Jia, Colin M Tice

Bioorg Med Chem Lett· January 2010

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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Colin M Tice, Zhenrong Xu, Jing Yuan, Robert D Simpson, Salvacion T Cacatian

Bioorg Med Chem Lett· July 2009

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Evaluation of solution and solid-phase approaches to the synthesis of libraries of alpha,alpha-disubstituted-alpha-acylaminoketones.
Javier Garcia, Ernesto G Mata, Colin M Tice, Robert E Hormann, Ernesto Nicolas

J Comb Chem· January 2006

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Highly flexible ligand binding pocket of ecdysone receptor: a single amino acid change leads to discrimination between two groups of nonsteroidal ecdysone agonists.
Mohan B Kumar, David W Potter, Robert E Hormann, Angela Edwards, Colin M Tice

J Biol Chem· June 2004

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Optimization of alpha-acylaminoketone ecdysone agonists for control of gene expression.
Colin M Tice, Robert E Hormann, Christine S Thompson, Jennifer L Friz, Caitlin K Cavanaugh

Bioorg Med Chem Lett· June 2003

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Synthesis and SAR of cis-1-benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems.
Howard C Smith, Caitlin K Cavanaugh, Jennifer L Friz, Christine S Thompson, Jessica A Saggers, Colin M Tice

Bioorg Med Chem Lett· June 2003

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