Publications by authors named "Edward Tasber"

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Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues.
Chunze Li, Bing Lu, Robert M Garbaccio, Edward S Tasber, Mark E Fraley

Biochem Pharmacol· May 2010

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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Antonella Converso, Timothy Hartingh, Robert M Garbaccio, Edward Tasber, Keith Rickert

Bioorg Med Chem Lett· February 2009

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Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Keith W Rickert, Michael Schaber, Maricel Torrent, Lou Anne Neilson, Edward S Tasber

Arch Biochem Biophys· January 2008

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Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.
Edward J Brnardic, Robert M Garbaccio, Mark E Fraley, Edward S Tasber, Justin T Steen

Bioorg Med Chem Lett· November 2007

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Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Robert M Garbaccio, Shaei Huang, Edward S Tasber, Mark E Fraley, Youwei Yan

Bioorg Med Chem Lett· November 2007

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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Robert M Garbaccio, Edward S Tasber, Lou Anne Neilson, Paul J Coleman, Mark E Fraley

Bioorg Med Chem Lett· October 2007

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Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Robert M Garbaccio, Mark E Fraley, Edward S Tasber, Christy M Olson, William F Hoffman

Bioorg Med Chem Lett· April 2006

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Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Mark E Fraley, Robert M Garbaccio, Kenneth L Arrington, William F Hoffman, Edward S Tasber

Bioorg Med Chem Lett· April 2006

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Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.
Zhicai Wu, Mark E Fraley, Mark T Bilodeau, Mildred L Kaufman, Edward S Tasber

Bioorg Med Chem Lett· February 2004

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