Publications by authors named "Matthew D Zimmerman"

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The Kinetics of Bedaquiline Diffusion in Tuberculous Cavities Open a Window for the Emergence of Resistance.
Annamarie E Bustion, Jacqueline P Ernest, Firat Kaya, Connie Silva, Jansy Sarathy, Matthew D Zimmerman

J Infect Dis· September 2025

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Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis.
Qiang Liu, Joshua B Wallach, Yahani P Jayasinghe, Mark R Sullivan, Julianna Proietto, Matthew D Zimmerman

bioRxiv· September 2025

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Tailored phenyl ureas eradicate drug-resistant by targeting mycolic acid cell wall assembly.
Dietrich Mostert, Josef Braun, Matthew D Zimmerman, Curtis A Engelhart, Sara Berndl

Chem Sci· May 2025

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Toward a Bactericidal Oral Drug Combination for the Treatment of Lung Disease.
Jickky Palmae Sarathy, Min Xie, Chui Fann Wong, Dereje A Negatu, Suyapa Rodriguez, Matthew D Zimmerman

ACS Infect Dis· April 2025

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Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.
Peter O Oluoch, Eun-Ik Koh, Megan K Proulx, Charlotte J Reames, Kadamba G Papavinasasundaram, Matthew D Zimmerman

Proc Natl Acad Sci U S A· March 2025

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Evolution of Small Molecule Inhibitors of Menaquinone Biosynthesis.
Pankaj Sharma, Quan Jiang, Shao-Gang Li, Elissa Ocke, Kholiswa Tsotetsi, Matthew D Zimmerman

J Med Chem· March 2025

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Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents.
Qiang Liu, Curtis A Engelhart, Joshua B Wallach, Divya Tiwari, Peng Ge, Matthew D Zimmerman

J Med Chem· February 2025

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Identification of Antituberculars with Favorable Potency and Pharmacokinetics through Structure-Based and Ligand-Based Modeling.
Vedang Warapande, Fanwang Meng, Alexandra Bozan, David E Graff, Jenna C Fromer, Matthew D Zimmerman

bioRxiv· February 2025

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Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408.
Jiuyu Liu, Pradeep B Lukka, Victoria A Ektnitphong, Keyur R Parmar, Santosh Wagh, Matthew D Zimmerman

Bioorg Med Chem Lett· November 2024

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Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
Allison A Bauman, Jansy P Sarathy, Firat Kaya, Lisa M Massoudi, Michael S Scherman, Matthew D Zimmerman

Antimicrob Agents Chemother· November 2024

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Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.
Peter O Oluoch, Eun-Ik Koh, Megan K Proulx, Charlotte J Reames, Kadamba G Papavinasasundaram, Matthew D Zimmerman

bioRxiv· September 2024

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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.
Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman

Viruses· July 2024

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Inhibitors of the Thioesterase Activity of Pks13 Discovered Using DNA-Encoded Chemical Library Screening.
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman

ACS Infect Dis· May 2024

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Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
Allison A Bauman, Jansy P Sarathy, Firat Kaya, Lisa M Massoudi, Michael S Scherman, Matthew D Zimmerman

bioRxiv· May 2024

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Small Molecule Benzothiophene with Efficacy in a Mouse Model of Drug-Resistant Infection.
Ricardo Gallardo-Macias, Riccardo Russo, Matthew Sherwood, Mark Jaskowski, Wissam Nasser, Matthew D Zimmerman

J Med Chem· January 2024

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Lung microenvironments harbor phenotypes with distinct treatment responses.
Nicholas D Walter, Jackie P Ernest, Christian Dide-Agossou, Allison A Bauman, Michelle E Ramey, Matthew D Zimmerman

Antimicrob Agents Chemother· September 2023

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Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Satish R Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Matthew D Zimmerman

J Med Chem· June 2023

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Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.
Dereje A Negatu, Rubén González Del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Matthew D Zimmerman

Antimicrob Agents Chemother· February 2023

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Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus .
Jickky Palmae Sarathy, Matthew D Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick

Antimicrob Agents Chemother· December 2022

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Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus.
Lea Mann, Uday S Ganapathy, Rana Abdelaziz, Markus Lang, Matthew D Zimmerman

Microbiol Spectr· December 2022

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Spatial quantitation of antibiotics in bone tissue compartments by laser-capture microdissection coupled with UHPLC-tandem mass spectrometry.
Firat Kaya, Matthew D Zimmerman, Rosleine Antilus-Sainte, Martin Gengenbacher, Claire L Carter

Anal Bioanal Chem· September 2022

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Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
Abdeldjalil Madani, Dereje A Negatu, Abdellatif El Marrouni, Randy R Miller, Christopher W Boyce, Matthew D Zimmerman

Antimicrob Agents Chemother· September 2022

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Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease.
Dereje A Negatu, Matthew D Zimmerman, Véronique Dartois, Thomas Dick

Antimicrob Agents Chemother· September 2022

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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis.
Shuqi Li, Nicholas C Poulton, Jesseon S Chang, Zachary A Azadian, Michael A DeJesus, Matthew D Zimmerman

Nat Microbiol· June 2022

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