Publications by authors named "Curtis A Engelhart"

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Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in .
Mengyun Zhang, Renee Allen, Lauren Ames, Curtis A Engelhart, Diana Quach

Antimicrob Agents Chemother· October 2025

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Common Biological Properties of MmpL3 Inhibitors.
Lauren Ames, Renee Allen, Helena I M Boshoff, Laura A T Cleghorn, Curtis A Engelhart

ACS Infect Dis· September 2025

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Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
Susan H Davis, Michael Mathieson, Kirsteen I Buchanan, Alice Dawson, Alasdair Smith, Curtis A Engelhart

J Med Chem· August 2025

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Tailored phenyl ureas eradicate drug-resistant by targeting mycolic acid cell wall assembly.
Dietrich Mostert, Josef Braun, Matthew D Zimmerman, Curtis A Engelhart, Sara Berndl

Chem Sci· May 2025

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Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of .
Simon R Green, Justin R Harrison, Stephen Thompson, Dinakaran Murugesan, M Daben J Libardo, Curtis A Engelhart

ACS Infect Dis· March 2025

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Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents.
Qiang Liu, Curtis A Engelhart, Joshua B Wallach, Divya Tiwari, Peng Ge

J Med Chem· February 2025

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Inhibitors of the Thioesterase Activity of Pks13 Discovered Using DNA-Encoded Chemical Library Screening.
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman

ACS Infect Dis· May 2024

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Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
Simon R Green, Caroline Wilson, Thomas C Eadsforth, Avinash S Punekar, Fabio K Tamaki, Curtis A Engelhart

J Med Chem· November 2023

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Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in .
Ritu Sharma, Travis E Hartman, Tiago Beites, Jee-Hyun Kim, Hyungjin Eoh, Curtis A Engelhart

mBio· August 2023

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Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis.
Pooja Hegde, Moyosore O Orimoloye, Sachin Sharma, Curtis A Engelhart, Dirk Schnappinger

Tuberculosis (Edinb)· May 2023

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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Simon R Green, Susan H Davis, Sebastian Damerow, Curtis A Engelhart, Michael Mathieson

Nat Commun· October 2022

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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis.
Shuqi Li, Nicholas C Poulton, Jesseon S Chang, Zachary A Azadian, Michael A DeJesus, Curtis A Engelhart

Nat Microbiol· June 2022

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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Curtis A Engelhart

J Med Chem· January 2022

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Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis.
Heng Wang, Min Xu, Curtis A Engelhart, Xi Zhang, Baohua Yan

J Biol Chem· August 2021

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Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.
Barbara Bosch, Michael A DeJesus, Nicholas C Poulton, Wenzhu Zhang, Curtis A Engelhart

Cell· August 2021

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Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.
Bei Shi Lee, Kiel Hards, Curtis A Engelhart, Erik J Hasenoehrl, Nitin P Kalia

EMBO Mol Med· January 2021

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Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in .
Shipra Grover, Curtis A Engelhart, Esther Pérez-Herrán, Wei Li, Katherine A Abrahams

ACS Infect Dis· January 2021

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Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Curtis A Engelhart

J Med Chem· January 2021

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Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Growth.
Peter C Ray, Margaret Huggett, Penelope A Turner, Malcolm Taylor, Laura A T Cleghorn, Curtis A Engelhart

ACS Omega· January 2021

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Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
Tiago Beites, Kathryn O'Brien, Divya Tiwari, Curtis A Engelhart, Shaun Walters

Nat Commun· October 2019

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Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.
Matthew R Bockman, Curtis A Engelhart, Julia D Cramer, Michael D Howe, Neeraj K Mishra

ACS Infect Dis· April 2019

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Opposing reactions in coenzyme A metabolism sensitize to enzyme inhibition.
Elaine Ballinger, John Mosior, Travis Hartman, Kristin Burns-Huang, Ben Gold, Curtis A Engelhart

Science· February 2019

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Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Sangmi Oh, Yumi Park, Curtis A Engelhart, Joshua B Wallach, Dirk Schnappinger

J Med Chem· November 2018

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Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.
Matthew R Bockman, Curtis A Engelhart, Surendra Dawadi, Peter Larson, Divya Tiwari

ACS Infect Dis· July 2018

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Targeting protein biotinylation enhances tuberculosis chemotherapy.
Divya Tiwari, Sae Woong Park, Maram M Essawy, Surendra Dawadi, Alan Mason, Curtis A Engelhart

Sci Transl Med· April 2018

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