Publications by authors named "Santosh Wagh"

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Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408.
Jiuyu Liu, Pradeep B Lukka, Victoria A Ektnitphong, Keyur R Parmar, Santosh Wagh

Bioorg Med Chem Lett· November 2024

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Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Keyur R Parmar, Pradeep B Lukka, Santosh Wagh, Zaid H Temrikar, Jiuyu Liu

Pharmaceutics· June 2023

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Discovery of ()-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Santosh Wagh

J Med Chem· March 2022

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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Santosh Wagh

J Med Chem· March 2022

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Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis.
Santosh Wagh, Chetan Rathi, Pradeep B Lukka, Keyur Parmar, Zaid Temrikar

Antimicrob Agents Chemother· October 2021

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Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
Mercedes Gonzalez-Juarrero, Pradeep B Lukka, Santosh Wagh, Amanda Walz, Jennifer Arab

ACS Infect Dis· October 2021

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Bioavailability testing of a newly developed clindamycin oral suspension in a pediatric porcine model.
Grace A Goode, Santosh J Wagh, David J Irby, Dejian Ma, Richard F Jacobs

Pharm Dev Technol· October 2019

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Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.
Prashanth K B Nagesh, Pallabita Chowdhury, Elham Hatami, Sonam Kumari, Vivek Kumar Kashyap, Santosh Wagh

ACS Appl Mater Interfaces· October 2019

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Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells.
Pallabita Chowdhury, Prashanth K B Nagesh, Elham Hatami, Santosh Wagh, Nirnoy Dan

J Colloid Interface Sci· February 2019

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Relative quantitation of endogenous proteins by quadrupole-time of flight and tandem mass spectrometry.
Shashyendra Singh Gautam, Santosh Wagh, Suresh Babu, Ravindra Gudihal, Sudha Rajagopalan

J Chromatogr B Analyt Technol Biomed Life Sci· February 2019

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Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.
Chetan Rathi, Pradeep B Lukka, Santosh Wagh, Richard E Lee, Anne J Lenaerts

Tuberculosis (Edinb)· January 2019

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Reverse Translation of US Food and Drug Administration Reviews of Oncology New Molecular Entities Approved in 2011-2017: Lessons Learned for Anticancer Drug Development.
Stephanie Faucette, Santosh Wagh, Ashit Trivedi, Karthik Venkatakrishnan, Neeraj Gupta

Clin Transl Sci· March 2018

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Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.
Sarmistha Sinha, Deepak Ahire, Santosh Wagh, Dibakar Mullick, Ramesh Sistla

Chem Res Toxicol· December 2014

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Practical and economical implementation of online H/D exchange in LC-MS.
Ravi P Shah, Amit Garg, Siva Prasad Putlur, Santosh Wagh, Vineet Kumar

Anal Chem· November 2013

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