Publications by authors named "Keyur Parmar"

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Characterization of CAR-T cellular kinetics and efficacy in solid tumor patients with and without prior lymphodepletion chemotherapy using a PBPK-PD model.
Keyur R Parmar, Agnish Dey, Angelia F Wang, Ganesh M Mugundu, Aman P Singh

J Pharmacokinet Pharmacodyn· October 2025

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Quantitative Chiral Separations on KRAS Inhibitor Sotorasib by UHPLC-MS/MS: Method Validation and Enantioselective Pharmacokinetics Assessment in Rat Plasma.
Jony Susanna Kandula, Keyur Parmar, A R Priyadharshni, Abhay Kumar, P Radhakrishnanand

Chirality· June 2025

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Antimicrobial Potential of Marine Sponge-Associated Bacillus velezensis and Stutzerimonas stutzeri from the Indian Coast: A Genome Mining and Metabolite Profiling Approach.
Heena U Devkar, Kartik Juyal, Narsinh L Thakur, Parvinder Kaur, Keyur Parmar

Curr Microbiol· May 2025

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Discovery of a potent and selective TRPC3 antagonist with neuroprotective effects.
Jiaxing Wang, Sicheng Zhang, Vijay K Boda, Hao Chen, Hyunseo Park, Keyur Parmar

Bioorg Med Chem· January 2025

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Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408.
Jiuyu Liu, Pradeep B Lukka, Victoria A Ektnitphong, Keyur R Parmar, Santosh Wagh

Bioorg Med Chem Lett· November 2024

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Phytochemically analysed extract of Ageratina adenophora (Sprengel) R.M.King & H. Rob. initiates caspase 3-dependant apoptosis in colorectal cancer cell: A synergistic approach with chemotherapeutic drugs.
Khaidem Devika Chanu, Soibam Thoithoisana, Amit Kar, Pulok Kumar Mukherjee, P Radhakrishnanand, Keyur Parmar

J Ethnopharmacol· March 2024

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Enantioselective polar-organic mode high-performance liquid chromatographic separation of lifitegrast on immobilized polysaccharide stationary phase and its application to pH-dependent chiral interconversion studies.
Jony Susanna Kandula, Veera Venkata Satya Prasanna Kumari Rayala, Keyur Parmar, Veerabhadra Swamy Ponnapalli, Mahendar Gantala

Chirality· February 2024

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Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Keyur R Parmar, Pradeep B Lukka, Santosh Wagh, Zaid H Temrikar, Jiuyu Liu

Pharmaceutics· June 2023

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Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.
Xufeng Cao, Dong Yang, Jyothi Parvathareddy, Yong-Kyu Chu, Eun Jung Kim, Keyur R Parmar

Sci Transl Med· April 2023

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Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation and .
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Keyur R Parmar

ACS Pharmacol Transl Sci· April 2023

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Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
Satyanarayana Pochampally, Kelli L Hartman, Rui Wang, Jiaxing Wang, Mi-Kyung Yun, Keyur Parmar

ACS Pharmacol Transl Sci· April 2023

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Intranasal delivery of darunavir improves brain drug concentrations in mice for effective HIV treatment.
Asit Kumar, Lina Zhou, Sandip Godse, Namita Sinha, Dejian Ma, Keyur Parmar

Biochem Biophys Rep· March 2023

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SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.
Shanshan Deng, Souvik Banerjee, Hao Chen, Satyanarayana Pochampally, Yuxi Wang, Keyur Parmar

Cancer Lett· February 2023

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Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis.
Santosh Wagh, Chetan Rathi, Pradeep B Lukka, Keyur Parmar, Zaid Temrikar

Antimicrob Agents Chemother· October 2021

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Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
Mercedes Gonzalez-Juarrero, Pradeep B Lukka, Santosh Wagh, Amanda Walz, Jennifer Arab, Keyur Parmar

ACS Infect Dis· October 2021

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X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Souvik Banerjee, Foyez Mahmud, Shanshan Deng, Lingling Ma, Mi-Kyung Yun, Keyur Parmar

J Med Chem· September 2021

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Detection of glutathione conjugates of amiodarone and its reactive diquinone metabolites in rat bile using mass spectrometry tools.
Keyur R Parmar, Shalu Jhajra, Saranjit Singh

Rapid Commun Mass Spectrom· May 2016

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