Publications by authors named "Andrew D Howard"

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Implications of the End-Stage Renal Disease Treatment Choices Model among U.S. Dialysis Providers.
Amber B Paulus, Andrew D Howard, Brandy A Vinson

Nephrol Nurs J· March 2021

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Barbara Pio, Harry R Chobanian, Yan Guo, Hubert Josien, William K Hagmann, Andrew D Howard

Bioorg Med Chem Lett· July 2019

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Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Bhagirath Chaurasia, Trevor S Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Andrew D Howard

Science· July 2019

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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Olga Rudenko, Jin Shang, Alexander Munk, Jeppe P Ekberg, Natalia Petersen, Andrew D Howard

Mol Metab· January 2019

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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.
Weiguo Liu, Pengcheng P Shao, Gui-Bai Liang, John Bawiec, Jiafang He, Andrew D Howard

ACS Med Chem Lett· November 2018

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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.
Weiguo Liu, Zahid Hussain, Yi Zang, Ramzi F Sweis, F Anthony Romero, Andrew D Howard

ACS Med Chem Lett· November 2018

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Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
Helen Y Chen, Christopher W Plummer, Dong Xiao, Harry R Chobanian, Duane DeMong, Andrew D Howard

ACS Med Chem Lett· July 2018

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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.
Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Andrew D Howard

PLoS One· November 2017

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GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Santhosh Satapati, Ying Qian, Margaret S Wu, Aleksandr Petrov, Ge Dai, Andrew D Howard

J Lipid Res· August 2017

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GPR40 reduces food intake and body weight through GLP-1.
Judith N Gorski, Michele J Pachanski, Joel Mane, Christopher W Plummer, Sarah Souza, Andrew D Howard

Am J Physiol Endocrinol Metab· July 2017

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Jun Lu, Noel Byrne, John Wang, Gerard Bricogne, Frank K Brown, Andrew D Howard

Nat Struct Mol Biol· July 2017

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Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Andrew D Howard

Bioorg Med Chem Lett· March 2017

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Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
Christopher W Plummer, Matthew J Clements, Helen Chen, Murali Rajagopalan, Hubert Josien, Andrew D Howard

ACS Med Chem Lett· February 2017

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GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
Jeppe H Ekberg, Maria Hauge, Line V Kristensen, Andreas N Madsen, Maja S Engelstoft, Andrew D Howard

Endocrinology· December 2016

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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Andrew D Howard

Bioorg Med Chem Lett· December 2016

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.
Liangqin Guo, Dann L Parker, Yi Zang, Ramzi F Sweis, Weiguo Liu, Andrew D Howard

ACS Med Chem Lett· December 2016

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The ESRD Quality Incentive Program: The Current Limitations of Evidence and Data to Develop Measures, Drive Improvement, and Incentivize Outcomes.
Louis H Diamond, Andrew D Howard

Adv Chronic Kidney Dis· November 2016

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Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.
Jin Shang, Jose M Castro-Perez, Xiaolan Shen, Yonghua Zhu, Haiying Liu, Andrew D Howard

Obesity (Silver Spring)· September 2016

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.
Shuwen He, Peter H Dobbelaar, Liangqin Guo, Zhixiong Ye, Jian Liu, Andrew D Howard

Bioorg Med Chem Lett· March 2016

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Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
Kaare V Grunddal, Cecilia F Ratner, Berit Svendsen, Felix Sommer, Maja S Engelstoft, Andrew D Howard

Endocrinology· January 2016

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Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists.
Zhong Lai, Shuwen He, Edward C Sherer, Zhicai Wu, Yang Yu, Andrew D Howard

Bioorg Med Chem Lett· September 2015

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Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.
Jin Shang, Jing Li, Mark P Keller, Hans E Hohmeier, Yong Wang, Andrew D Howard

Mol Endocrinol· September 2015

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.
Shrenik K Shah, Shuwen He, Liangqin Guo, Quang Truong, Hongbo Qi, Andrew D Howard

ACS Med Chem Lett· May 2015

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Correlates of change in health care worker seasonal influenza vaccination rates among dialysis facilities.
Janet R Lynch, Nancy Armistead, Brandy B Vinson, Andrew D Howard

Am J Infect Control· April 2015

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GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Andrew D Howard

Mol Metab· January 2015

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