Publications by authors named "Andrew D Huber"

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PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
Andrew D Huber, Wenwei Lin, Young-Hwan Jung, Shyaron Poudel, Guangwei Yang

Nat Commun· November 2025

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Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators.
Andrew D Huber, Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu

Structure· October 2025

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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.
Andrew D Huber, Wenwei Lin, Shyaron Poudel, Darcie J Miller, Taosheng Chen

Structure· December 2024

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Addition/Correction to "First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy".
Andrew D Huber, Young-Hwan Jung, Yongtao Li, Wenwei Lin, Jing Wu

J Med Chem· December 2024

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First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy.
Andrew D Huber, Young-Hwan Jung, Yongtao Li, Wenwei Lin, Jing Wu

J Med Chem· October 2024

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A new mode of inhibition.
Andrew D Huber, Taosheng Chen

Elife· August 2024

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CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
Ming Shao, Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D Huber

Genes Dis· July 2024

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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li

Nat Commun· May 2024

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Regulation of PXR in drug metabolism: chemical and structural perspectives.
Rebecca R Florke Gee, Andrew D Huber, Taosheng Chen

Expert Opin Drug Metab Toxicol· March 2024

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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Andrew D Huber, Shyaron Poudel, Jing Wu, Darcie J Miller, Wenwei Lin

Nucleic Acids Res· February 2024

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.
Andrew D Huber, Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu

Structure· December 2023

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The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation.
Rebecca R Florke Gee, Andrew D Huber, Jing Wu, Richa Bajpai, Allister J Loughran

Acta Pharm Sin B· November 2023

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Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus.
Dandan Liu, Tanya P Ndongwe, Juan Ji, Andrew D Huber, Eleftherios Michailidis

Viruses· April 2023

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Wenwei Lin, Andrew D Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman

Proc Natl Acad Sci U S A· March 2023

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Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond.
Shyaron Poudel, Andrew D Huber, Taosheng Chen

Drug Metab Dispos· February 2023

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SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
Andrew D Huber, Yongtao Li, Wenwei Lin, Annalise N Galbraith, Ashutosh Mishra

ACS Med Chem Lett· August 2022

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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber

Nucleic Acids Res· April 2022

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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Jingheng Wang, Cameron D Buchman, Jayaraman Seetharaman, Darcie J Miller, Andrew D Huber

J Am Chem Soc· November 2021

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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.
Andrew D Huber, William C Wright, Wenwei Lin, Kinjal Majumder, Jonathan A Low

Cell Mol Life Sci· January 2021

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CITCO Directly Binds to and Activates Human Pregnane X Receptor.
Wenwei Lin, Monicah Bwayi, Jing Wu, Yongtao Li, Sergio C Chai, Andrew D Huber

Mol Pharmacol· March 2020

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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
William C Wright, Jude Chenge, Jingheng Wang, Hazel M Girvan, Lei Yang, Andrew D Huber

J Med Chem· February 2020

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Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.
Dandan Liu, Philip R Tedbury, Shuiyun Lan, Andrew D Huber, Maritza N Puray-Chavez

Viruses· November 2019

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Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.
Maritza N Puray-Chavez, Mahmoud H Farghali, Vincent Yapo, Andrew D Huber, Dandan Liu

Viruses· July 2019

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Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.
Jing Tang, Ha T Do, Andrew D Huber, Mary C Casey, Karen A Kirby

Eur J Med Chem· March 2019

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Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment.
Andrew D Huber, Taosheng Chen

Cell Chem Biol· March 2019

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