Publications by authors named "Andrew D Morley"

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Fragment-based hit identification: thinking in 3D.
Andrew D Morley, Angelo Pugliese, Kristian Birchall, Justin Bower, Paul Brennan

Drug Discov Today· December 2013

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Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
James J Crawford, Peter W Kenny, Jonathan Bowyer, Calum R Cook, Jonathan E Finlayson, Andrew D Morley

J Med Chem· October 2012

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Alexander G Dossetter, Jonathan Bowyer, Calum R Cook, James J Crawford, Jonathan E Finlayson, Andrew D Morley

Bioorg Med Chem Lett· September 2012

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(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
Alexander G Dossetter, Howard Beeley, Jonathan Bowyer, Calum R Cook, James J Crawford, Andrew D Morley

J Med Chem· July 2012

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Lead optimisation of pyrazoles as novel FPR1 antagonists.
Andrew D Morley, Sarah King, Bryan Roberts, Sarah Lever, Barry Teobald

Bioorg Med Chem Lett· January 2012

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Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2.
Chris De Savi, Andrew D Morley, Ian Nash, Galith Karoutchi, Ken Page

Bioorg Med Chem Lett· January 2012

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Discovery of pyrazoles as novel FPR1 antagonists.
Andrew D Morley, Andrew Cook, Sarah King, Bryan Roberts, Sarah Lever

Bioorg Med Chem Lett· November 2011

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Selective non zinc binding inhibitors of MMP13.
Chris De Savi, Andrew D Morley, Attilla Ting, Ian Nash, Kostas Karabelas

Bioorg Med Chem Lett· July 2011

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Dipeptidyl nitrile inhibitors of Cathepsin L.
Nabil Asaad, Paul A Bethel, Michelle D Coulson, Jack E Dawson, Susannah J Ford, Andrew D Morley

Bioorg Med Chem Lett· August 2009

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Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
David Elliot, Eleanor Henshaw, Philip A MacFaul, Andrew D Morley, Peter Newham

Bioorg Med Chem Lett· August 2009

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Design of selective Cathepsin inhibitors.
Paul A Bethel, Stefan Gerhardt, Emma V Jones, Peter W Kenny, Galith I Karoutchi, Andrew D Morley

Bioorg Med Chem Lett· August 2009

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5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Andrew D Morley, Peter W Kenny, Brenda Burton, Robert A Heald, Philip A Macfaul

Bioorg Med Chem Lett· March 2009

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A simple in vitro assay for assessing the reactivity of nitrile containing compounds.
Philip A MacFaul, Andrew D Morley, James J Crawford

Bioorg Med Chem Lett· February 2009

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Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Paul R O Whittamore, Matthew S Addie, Stuart N L Bennett, Alan M Birch, Michael Butters, Andrew D Morley

Bioorg Med Chem Lett· November 2006

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Structure-based design of protein tyrosine phosphatase-1B inhibitors.
Emma Black, Jason Breed, Alexander L Breeze, Kevin Embrey, Robert Garcia, Andrew D Morley

Bioorg Med Chem Lett· May 2005

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