Publications by authors named "Jason Breed"

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Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1.
Silvia Bonomo, Floriane Gibault, Sharan K Bagal, J Henry Blackwell, Jason Breed

ACS Med Chem Lett· October 2025

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Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.
Simon C C Lucas, Alexander G Milbradt, Jason Breed, Erwin De Genst, Anne Jackson

ACS Med Chem Lett· August 2025

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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold.
Roger Castells-Graells, Kyle Meador, Mark A Arbing, Michael R Sawaya, Morgan Gee, Jason Breed

Proc Natl Acad Sci U S A· September 2023

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS with Demonstrable CNS Penetration.
Jason G Kettle, Sharan K Bagal, Derek Barratt, Michael S Bodnarchuk, Scott Boyd, Jason Breed

J Med Chem· July 2023

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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo

J Med Chem· February 2023

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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Scott Boyd, Jason Breed

J Med Chem· May 2022

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Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
James S Scott, Thomas A Moss, Amber Balazs, Bernard Barlaam, Jason Breed

J Med Chem· December 2020

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS.
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Jason Breed

J Med Chem· May 2020

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
Richard A Ward, Mark J Anderton, Paul Bethel, Jason Breed, Calum Cook

J Med Chem· December 2019

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Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.
James S Scott, Jason Breed, Rodrigo J Carbajo, Paul R Davey, Ryan Greenwood

ACS Med Chem Lett· October 2019

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KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey

Nat Commun· June 2019

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Computational Design of Epitope-Specific Functional Antibodies.
Guy Nimrod, Sharon Fischman, Mark Austin, Asael Herman, Feenagh Keyes, Jason Breed

Cell Rep· November 2018

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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Bin Yang, Melissa M Vasbinder, Alexander W Hird, Qibin Su, Haixia Wang, Jason Breed

J Med Chem· February 2018

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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang

Nat Commun· July 2017

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Holly H Soutter, Paolo Centrella, Matthew A Clark, John W Cuozzo, Christoph E Dumelin, Jason Breed

Proc Natl Acad Sci U S A· December 2016

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MTH1 Substrate Recognition--An Example of Specific Promiscuity.
J Willem M Nissink, Michal Bista, Jason Breed, Nikki Carter, Kevin Embrey

PLoS One· August 2016

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Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.
Harshnira Patani, Tom D Bunney, Nethaji Thiyagarajan, Richard A Norman, Derek Ogg, Jason Breed

Oncotarget· April 2016

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Jason G Kettle, Husam Alwan, Michal Bista, Jason Breed, Nichola L Davies

J Med Chem· March 2016

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Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.
Julie A Tucker, Tobias Klein, Jason Breed, Alexander L Breeze, Ross Overman

Structure· December 2014

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Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
Mark Furber, Anna-Karin Tiden, Philip Gardiner, Antonio Mete, Rhonan Ford, Jason Breed

J Med Chem· March 2014

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Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
Vibha Oza, Susan Ashwell, Lynsie Almeida, Patrick Brassil, Jason Breed

J Med Chem· June 2012

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Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
Richard A Norman, Anne-Kathrin Schott, David M Andrews, Jason Breed, Kevin M Foote

J Med Chem· June 2012

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Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Vibha Oza, Susan Ashwell, Patrick Brassil, Jason Breed, Jaychandran Ezhuthachan

Bioorg Med Chem Lett· March 2012

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Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
Oluyinka M Green, Andrew R McKenzie, Adam B Shapiro, Ludovic Otterbein, Haihong Ni, Jason Breed

Bioorg Med Chem Lett· February 2012

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Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.
Vibha Oza, Susan Ashwell, Patrick Brassil, Jason Breed, Chun Deng

Bioorg Med Chem Lett· September 2010

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