Publications by authors named "Andrew D Wells"

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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Khanh B Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Andrew D Wells

Genome Biol· December 2025

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GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.
Mitchell Conery, James A Pippin, Yadav Wagley, Khanh Trang, Matthew C Pahl, Andrew D Wells

Genome Biol· October 2025

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Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal B Patel, Daina Eiser, Michael Mobaraki, Andrew D Wells

Gut· October 2025

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Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets.
Rohit Thakur, Mai Xu, Hayley Sowards, Joshuah Yon, Lea Jessop, Andrew D Wells

Am J Hum Genet· July 2025

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Shared and unique 3D genomic features of substance use disorders across multiple cell types.
Khanh B Trang, Alessandra Chesi, Sylvanus Toikumo, James A Pippin, Matthew C Pahl, Andrew D Wells

medRxiv· June 2025

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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Khanh B Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, Andrew D Wells

medRxiv· May 2025

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Trans-ancestry genome-wide association meta-analysis of gallstone disease.
Junghyun Lim, Marijana Vujkovic, Michael G Levin, Kim Lorenz, Benjamin F Voight, Andrew D Wells

medRxiv· March 2025

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Andrew D Wells

Elife· January 2025

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GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.
Mitchell Conery, James A Pippin, Yadav Wagley, Khanh Trang, Matthew C Pahl, Andrew D Wells

bioRxiv· December 2024

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Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C.
Nicholas A Wachowski, James A Pippin, Keith Boehm, Sumei Lu, Michelle E Leonard, Andrew D Wells

Diabetologia· December 2024

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Angiotensin receptor blockers modulate the lupus CD4+ T cell epigenome characterized by TNF family-linked signaling.
Andrew P Hart, Jonathan J Kotzin, Steffan W Schulz, Jonathan S Dunham, Alison L Keenan, Andrew D Wells

JCI Insight· December 2024

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Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of -regulation.
Rohit Thakur, Mai Xu, Hayley Sowards, Joshuah Yon, Lea Jessop, Andrew D Wells

medRxiv· November 2024

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The common variable immunodeficiency IgM repertoire narrowly recognizes erythrocyte and platelet glycans.
Carole Le Coz, Melissa Trofa, Dorothy L Butler, Samuel Yoon, Tian Tian, Andrew D Wells

J Allergy Clin Immunol· September 2024

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Dynamic chromatin architecture identifies new autoimmune-associated enhancers for and novel genes regulating CD4+ T cell activation.
Matthew C Pahl, Prabhat Sharma, Rajan M Thomas, Zachary Thompson, Zachary Mount, Andrew D Wells

Elife· September 2024

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Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal Patel, Daina Eiser, Michael Mobaraki, Andrew D Wells

medRxiv· September 2024

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Andrew D Wells

medRxiv· August 2024

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Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates at the locus.
Elizabeth A Burton, Mariana Argenziano, Kieona Cook, Molly Ridler, Sumei Lu, Andrew D Wells

bioRxiv· August 2024

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Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
Shilpa Sonti, Sheridan H Littleton, Matthew C Pahl, Amber J Zimmerman, Alessandra Chesi, Andrew D Wells

Sleep· July 2024

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Osteoporosis GWAS-implicated locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels.
Gurcharan Kaur, James A Pippin, Solomon Chang, Justin Redmond, Alessandra Chesi, Andrew D Wells

JBMR Plus· May 2024

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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, Kieona Cook, Nicole DeBruyne, Andrew D Wells

Cell Genom· May 2024

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Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Rajan M Thomas, Matthew C Pahl, Liqing Wang, Struan F A Grant, Wayne W Hancock, Andrew D Wells

Elife· April 2024

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Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements.
Matthew C Pahl, Lin Liu, James A Pippin, Yadav Wagley, Keith Boehm, Andrew D Wells

EBioMedicine· March 2024

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Perturbation of the insomnia GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, .
Shilpa Sonti, Sheridan H Littleton, Matthew C Pahl, Amber J Zimmerman, Alessandra Chesi, Andrew D Wells

bioRxiv· August 2023

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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of .
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, Kieona Cook, Nicole DeBruyne, Andrew D Wells

bioRxiv· August 2023

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Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures.
Tatiana A Karakasheva, Yusen Zhou, Hongbo M Xie, Gloria E Soto, Tiana D Johnson, Andrew D Wells

Gastro Hep Adv· May 2023

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