Publications by authors named "Andrew Grottick"

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Diazepine Agonists of the 5-HT Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352).
Albert Ren, Xiuwen Zhu, Juerg Lehmann, Michelle Kasem, Thomas O Schrader, Andrew J Grottick

J Med Chem· June 2025

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Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D but not nicotinic agonist.
Andrew J Grottick, David L MacQueen, Samuel A Barnes, Chris Carroll, Erin K Sanabria

Psychopharmacology (Berl)· April 2021

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Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT receptor.
Thomas O Schrader, Xiuwen Zhu, Michelle Kasem, Albert Ren, Chunyan Liu, Andrew J Grottick

Bioorg Med Chem Lett· April 2021

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Editorial: Dopaminergic Alterations in Schizophrenia.
Mark D Tricklebank, Carol Tamminga, Andrew Grottick, Pierre M Llorca, Silvia Gatti McArthur

Front Neurosci· March 2021

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GPR52 agonists attenuate ropinirole-induced preference for uncertain outcomes.
Brittney Russell, Michael M Barrus, Melanie Tremblay, Lawrence Ma, Kelly Hrelja, Andrew J Grottick

Behav Neurosci· February 2021

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Discovery of a lead series of potent benzodiazepine 5-HT receptor agonists with high selectivity in functional and binding assays.
Albert Ren, Xiuwen Zhu, Konrad Feichtinger, Juerg Lehman, Michelle Kasem, Andrew J Grottick

Bioorg Med Chem Lett· March 2020

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Discovery of APD371: Identification of a Highly Potent and Selective CB Agonist for the Treatment of Chronic Pain.
Sangdon Han, Lars Thoresen, Jae-Kyu Jung, Xiuwen Zhu, Jayant Thatte, Andrew J Grottick

ACS Med Chem Lett· December 2017

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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT receptor.
Thomas O Schrader, Michelle Kasem, Albert Ren, Konrad Feichtinger, Bilal Al Doori, Andrew J Grottick

Bioorg Med Chem Lett· December 2016

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Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat.
Andrew J Grottick, Kevin Whelan, Erin K Sanabria, Dominic P Behan, Michael Morgan

Psychopharmacology (Berl)· June 2015

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Diet-induced models of obesity (DIO) in rodents.
Didier Bagnol, Hussien A Al-Shamma, Dominic Behan, Kevin Whelan, Andrew J Grottick

Curr Protoc Neurosci· April 2012

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Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, Andrew J Grottick

Bioorg Med Chem Lett· March 2012

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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.
Graeme Semple, Juerg Lehmann, Amy Wong, Albert Ren, Marc Bruce, Andrew J Grottick

Bioorg Med Chem Lett· February 2012

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Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Graeme Semple, Vincent J Santora, Jeffrey M Smith, Jonathan A Covel, Rena Hayashi, Andrew J Grottick

Bioorg Med Chem Lett· January 2012

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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
Graeme Semple, Albert Ren, Beatriz Fioravanti, Guillherme Pereira, Imelda Calderon, Andrew J Grottick

Bioorg Med Chem Lett· May 2011

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Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, Andrew J Grottick

J Med Chem· August 2010

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Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia.
Hussien A Al-Shamma, Christen Anderson, Emil Chuang, Remy Luthringer, Andrew J Grottick

J Pharmacol Exp Ther· January 2010

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Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Sangdon Han, Andrew J Grottick

Bioorg Med Chem Lett· November 2009

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Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.
Jonathan A Covel, Vincent J Santora, Jeffrey M Smith, Rena Hayashi, Charlemagne Gallardo, Andrew J Grottick

J Med Chem· September 2009

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Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
Graeme Semple, Beatriz Fioravanti, Guillherme Pereira, Imelda Calderon, Jane Uy, Andrew J Grottick

J Med Chem· September 2008

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Novel H3 receptor antagonists with improved pharmacokinetic profiles.
Vincent J Santora, Jonathan A Covel, Rena Hayashi, Brian J Hofilena, Jason B Ibarra, Andrew J Grottick

Bioorg Med Chem Lett· July 2008

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Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
William J Thomsen, Andrew J Grottick, Frederique Menzaghi, Hazel Reyes-Saldana, Stephen Espitia

J Pharmacol Exp Ther· May 2008

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A new family of H3 receptor antagonists based on the natural product Conessine.
Vincent J Santora, Jonathan A Covel, Rena Hayashi, Brian J Hofilena, Jason B Ibarra, Andrew J Grottick

Bioorg Med Chem Lett· February 2008

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Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Brian M Smith, Jeffrey M Smith, James H Tsai, Jeffrey A Schultz, Charles A Gilson, Andrew J Grottick

J Med Chem· January 2008

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The potential use of selective 5-HT2C agonists in treating obesity.
Brian M Smith, William J Thomsen, Andrew J Grottick

Expert Opin Investig Drugs· March 2006

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Neurotransmission- and cellular stress-related gene expression associated with prepulse inhibition in mice.
Andrew J Grottick, Didier Bagnol, Shirley Phillips, Jeffrey McDonald, Dominic P Behan

Brain Res Mol Brain Res· September 2005

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