Publications by authors named "Graeme Semple"

Claim this Profile
D
Diazepine Agonists of the 5-HT Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352).
Albert Ren, Xiuwen Zhu, Juerg Lehmann, Michelle Kasem, Thomas O Schrader, Graeme Semple

J Med Chem· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT receptor.
Thomas O Schrader, Xiuwen Zhu, Michelle Kasem, Albert Ren, Chunyan Liu, Graeme Semple

Bioorg Med Chem Lett· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a lead series of potent benzodiazepine 5-HT receptor agonists with high selectivity in functional and binding assays.
Albert Ren, Xiuwen Zhu, Konrad Feichtinger, Juerg Lehman, Michelle Kasem, Graeme Semple

Bioorg Med Chem Lett· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
Ibragim Gaidarov, John Adams, John Frazer, Todd Anthony, Xiaohua Chen, Graeme Semple

Cell Signal· October 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor.
Ibragim Gaidarov, Todd Anthony, Joel Gatlin, Xiaohua Chen, David Mills, Graeme Semple

Pharmacol Res· May 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of APD371: Identification of a Highly Potent and Selective CB Agonist for the Treatment of Chronic Pain.
Sangdon Han, Lars Thoresen, Jae-Kyu Jung, Xiuwen Zhu, Jayant Thatte, Graeme Semple

ACS Med Chem Lett· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
Thuy-Anh Tran, Bryan Kramer, Young-Jun Shin, Pureza Vallar, P Douglas Boatman, Graeme Semple

J Med Chem· February 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT receptor.
Thomas O Schrader, Michelle Kasem, Albert Ren, Konrad Feichtinger, Bilal Al Doori, Graeme Semple

Bioorg Med Chem Lett· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series.
Sangdon Han, Sanju Narayanan, Sun Hee Kim, Imelda Calderon, Xiuwen Zhu, Graeme Semple

Bioorg Med Chem Lett· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Thuy-Anh Tran, Young-Jun Shin, Bryan Kramer, Juyi Choi, Ning Zou, Graeme Semple

Bioorg Med Chem Lett· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.
Sangdon Han, Lars Thoresen, Xiuwen Zhu, Sanju Narayanan, Jae-Kyu Jung, Graeme Semple

Bioorg Med Chem Lett· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.
Daniel J Buzard, Sun Hee Kim, Luis Lopez, Andrew Kawasaki, Xiuwen Zhu, Graeme Semple

ACS Med Chem Lett· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
(
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
Daniel J Buzard, Luis Lopez, Jeanne Moody, Andrew Kawasaki, Thomas O Schrader, Graeme Semple

ACS Med Chem Lett· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Brett Lauring, Andrew K P Taggart, James R Tata, Richard Dunbar, Luzelena Caro, Graeme Semple

Sci Transl Med· August 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
(
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
P Douglas Boatman, Brett Lauring, Thomas O Schrader, Michelle Kasem, Benjamin R Johnson, Graeme Semple

J Med Chem· April 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, Graeme Semple

Bioorg Med Chem Lett· March 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.
Graeme Semple, Juerg Lehmann, Amy Wong, Albert Ren, Marc Bruce

Bioorg Med Chem Lett· February 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Graeme Semple, Vincent J Santora, Jeffrey M Smith, Jonathan A Covel, Rena Hayashi

Bioorg Med Chem Lett· January 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).
Stefan Offermanns, Steven L Colletti, Timothy W Lovenberg, Graeme Semple, Alan Wise

Pharmacol Rev· June 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
Graeme Semple, Albert Ren, Beatriz Fioravanti, Guillherme Pereira, Imelda Calderon

Bioorg Med Chem Lett· May 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, Graeme Semple

J Med Chem· August 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.
Yifeng Xiong, Bradley R Teegarden, Jin-Sun Karoline Choi, Sonja Strah-Pleynet, Marc Decaire, Graeme Semple

J Med Chem· June 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
P Douglas Boatman, Thomas O Schrader, Michelle Kasem, Benjamin R Johnson, Philip J Skinner, Graeme Semple

Bioorg Med Chem Lett· May 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.
Graeme Semple

IDrugs· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Sangdon Han

Bioorg Med Chem Lett· November 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis