Publications by authors named "John Frazer"

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Mechanisms of constitutive and agonist-induced 5-HT internalization, persistent endosomal signaling and paradoxical regulation of agonist pharmacology.
Ibragim Gaidarov, John Frazer, Xiaohua Chen, Huong Dang, Isabel Cordova

Cell Signal· July 2025

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Diazepine Agonists of the 5-HT Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352).
Albert Ren, Xiuwen Zhu, Juerg Lehmann, Michelle Kasem, Thomas O Schrader, John Frazer

J Med Chem· June 2025

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Changes in arterial pH do not explain the reductions in ionised calcium observed during COVID-19 infection.
John Scott Frazer, Robin Lucas-Evans, Asghar Dayala, Dennis A Mlangeni

Adv Med Sci· March 2024

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Trends in medication use at the onset of and during the COVID-19 pandemic in the Republic of Ireland: An interrupted time series study.
Molly Mattsson, Jung Ah Hong, John Scott Frazer, Glenn Ross Frazer, Frank Moriarty

Basic Clin Pharmacol Toxicol· February 2024

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A Case of Acute Intermittent Porphyria Leading to Severe Disability in a Young 21-Year-Old Female.
Adil Ramzan, Jenny Jia Ling Cao, John S Frazer, Penelope Stein, Shakeel Ahmad

Cureus· February 2023

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Analysis of primary care prescription trends in England during the COVID-19 pandemic compared against a predictive model.
John Scott Frazer, Glenn Ross Frazer

Fam Med Community Health· August 2021

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Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT receptor.
Thomas O Schrader, Xiuwen Zhu, Michelle Kasem, Albert Ren, Chunyan Liu, John Frazer

Bioorg Med Chem Lett· April 2021

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Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.
Cian Wade, John Scott Frazer, Evelyn Qian, Lien M Davidson, Suzanne Dash

Lancet Child Adolesc Health· October 2020

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Emerging patterns of hypercoagulability associated with critical COVID-19: A review.
John Scott Frazer, Angharad Joanna Tyrynis Everden

Trends Anaesth Crit Care· October 2020

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GP prescribing in Northern Ireland by deprivation index: retrospective analysis.
John Scott Frazer, Glenn Ross Frazer

Fam Med Community Health· June 2020

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Involvement of the open-source community in combating the worldwide COVID-19 pandemic: a review.
John Scott Frazer, Amelia Shard, James Herdman

J Med Eng Technol· May 2020

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Discovery of a lead series of potent benzodiazepine 5-HT receptor agonists with high selectivity in functional and binding assays.
Albert Ren, Xiuwen Zhu, Konrad Feichtinger, Juerg Lehman, Michelle Kasem, John Frazer

Bioorg Med Chem Lett· March 2020

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Zebrafish MYC-induced leukemia models: unique systems to study B and T cell acute lymphoblastic leukemia.
Chiara Borga, John Kimble Frazer

Int J Hematol Oncol· February 2019

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Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
Ibragim Gaidarov, John Adams, John Frazer, Todd Anthony, Xiaohua Chen

Cell Signal· October 2018

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Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report.
Stanton Goldman, Lynette Smith, Paul Galardy, Sherrie L Perkins, John Kimble Frazer

Br J Haematol· November 2014

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Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.
David J Unett, Joel Gatlin, Todd L Anthony, Daniel J Buzard, Steve Chang, John Frazer

J Pharmacol Exp Ther· December 2013

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Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, John M Frazer

Bioorg Med Chem Lett· March 2012

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Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Graeme Semple, Vincent J Santora, Jeffrey M Smith, Jonathan A Covel, Rena Hayashi, John Frazer

Bioorg Med Chem Lett· January 2012

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A pediatric B lineage leukemia with coincident MYC and MLL translocations.
Nathan D Meeker, Athena M Cherry, Charles D Bangs, John Kimble Frazer

J Pediatr Hematol Oncol· March 2011

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Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.
Yifeng Xiong, Brett Ullman, Jin-Sun Karoline Choi, Martin Cherrier, Sonja Strah-Pleynet, John M Frazer

J Med Chem· August 2010

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Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.
Yifeng Xiong, Bradley R Teegarden, Jin-Sun Karoline Choi, Sonja Strah-Pleynet, Marc Decaire, John Frazer

J Med Chem· June 2010

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Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.
Bradley R Teegarden, Hongmei Li, Honnappa Jayakumar, Sonja Strah-Pleynet, Peter I Dosa, John M Frazer

J Med Chem· March 2010

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APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology.
John W Adams, Juan Ramirez, Yunqing Shi, William Thomsen, John Frazer

J Pharmacol Exp Ther· October 2009

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Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.
Jonathan A Covel, Vincent J Santora, Jeffrey M Smith, Rena Hayashi, Charlemagne Gallardo, John Frazer

J Med Chem· September 2009

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Who are sexual offenders? A survey of pre-trial psychiatric reports.
Bharathi Balasundaram, John B Frazer, Peter J W Wood

Med Sci Law· January 2009

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