Publications by authors named "Andrew Hughson"

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Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.
Byron Caughey, Efrosini Artikis, Daniel Shoup, Christina D Orrú, Parvez Alam, Andrew G Hughson

Microbiol Mol Biol Rev· December 2025

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Evidence against efficient spontaneous disassembly of prions into small oligomers.
Daniel Shoup, Andrew G Hughson, Brent Race, Parvez Alam, Daniel Dulebohn

J Biol Chem· August 2025

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Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study.
Christina D Orrú, David P Vaughan, Nirosen Vijiaratnam, Raquel Real, Alejandro Martinez-Carrasco, Andrew G Hughson

Lancet Neurol· July 2025

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Elevated Cerebrospinal Fluid α-Synuclein Seeding Activity Predicts Central Lewy Body Diseases.
David S Goldstein, Parvez Alam, Patti Sullivan, Courtney Holmes, Janna Gelsomino, Andrew G Hughson

Mov Disord Clin Pract· May 2025

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A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens.
Sabiha Parveen, Parvez Alam, Christina D Orrù, Sarah Vascellari, Andrew G Hughson

NPJ Biosens· February 2025

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Sodium hypochlorite inactivation of human CJD prions.
Bradley R Groveman, Brent Race, Andrew G Hughson, Cathryn L Haigh

PLoS One· November 2024

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Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer.
Parvez Alam, Forrest Hoyt, Efrosini Artikis, Jakub Soukup, Andrew G Hughson

Acta Neuropathol· October 2024

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Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids.
Bradley R Groveman, Katie Williams, Brent Race, Simote Foliaki, Tina Thomas, Andrew G Hughson

Emerg Infect Dis· June 2024

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Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces.
Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia

PLoS Pathog· April 2024

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Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases.
Weiguanliu Zhang, Christina D Orrú, Aaron Foutz, Mingxuan Ding, Jue Yuan, Andrew G Hughson

Acta Neuropathol· January 2024

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Efficacy of Wex-cide 128 disinfectant against multiple prion strains.
Chase Baune, Bradley R Groveman, Andrew G Hughson, Tina Thomas, Barry Twardoski

PLoS One· August 2023

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Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.
Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Andrew G Hughson

Acta Neuropathol· July 2023

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Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease.
Tze How Mok, Akin Nihat, Nour Majbour, Danielle Sequeira, Leah Holm-Mercer, Andrew G Hughson

Brain· June 2023

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α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients.
Sarah Vascellari, Christina D Orrù, Bradley R Groveman, Sabiha Parveen, Giuseppe Fenu, Andrew G Hughson

PLoS Pathog· June 2023

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Sporadic Creutzfeldt-Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice.
Bradley R Groveman, Brent Race, Simote T Foliaki, Katie Williams, Andrew G Hughson

Acta Neuropathol Commun· February 2023

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Second passage experiments of chronic wasting disease in transgenic mice overexpressing human prion protein.
Brent Race, Chase Baune, Katie Williams, James F Striebel, Andrew G Hughson

Vet Res· December 2022

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Cryo-EM of prion strains from the same genotype of host identifies conformational determinants.
Forrest Hoyt, Parvez Alam, Efrosini Artikis, Cindi L Schwartz, Andrew G Hughson

PLoS Pathog· November 2022

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Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains.
Forrest Hoyt, Heidi G Standke, Efrosini Artikis, Cindi L Schwartz, Bryan Hansen, Andrew G Hughson

Nat Commun· July 2022

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Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease.
Sara Hall, Christina D Orrù, Geidy E Serrano, Douglas Galasko, Andrew G Hughson

Acta Neuropathol Commun· June 2022

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Reduction of Chronic Wasting Disease Prion Seeding Activity following Digestion by Mountain Lions.
Chase Baune, Lisa L Wolfe, Kristen C Schott, Karen A Griffin, Andrew G Hughson

mSphere· December 2021

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High-resolution structure and strain comparison of infectious mammalian prions.
Allison Kraus, Forrest Hoyt, Cindi L Schwartz, Bryan Hansen, Efrosini Artikis, Andrew G Hughson

Mol Cell· November 2021

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High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.
Marco J Russo, Christina D Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R Groveman, Andrew G Hughson

Acta Neuropathol Commun· November 2021

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Correction to: High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.
Marco J Russo, Christina D Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R Groveman, Andrew G Hughson

Acta Neuropathol Commun· November 2021

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Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear.
Natalia C Ferreira, Jorge M Charco, Jakob Plagenz, Christina D Orru, Nathanial D Denkers, Andrew G Hughson

Sci Rep· April 2021

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Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt-Jakob disease.
Bradley R Groveman, Natalia C Ferreira, Simote T Foliaki, Ryan O Walters, Clayton W Winkler, Andrew G Hughson

Sci Rep· March 2021

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