Publications by authors named "Simote Foliaki"

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Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis.
Clayton W Winkler, Benjamin Schwarz, Katie Williams, Sara Alehashemi, Simote T Foliaki

bioRxiv· August 2025

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Prion-induced ferroptosis is facilitated by RAC3.
Hao Peng, Susanne Pfeiffer, Borys Varynskyi, Marina Qiu, Chanikarn Srinark, Simote T Foliaki

Nat Commun· June 2025

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Limbic system synaptic dysfunctions associated with prion disease onset.
Simote T Foliaki, Bradley R Groveman, Emmett A Dews, Katie Williams, Hadil El Soufi

Acta Neuropathol Commun· December 2024

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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.
Feizhi Song, Valerija Kovac, Behnam Mohammadi, Jessica L Littau, Franka Scharfenberg, Simote T Foliaki

Acta Neuropathol· July 2024

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Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids.
Bradley R Groveman, Katie Williams, Brent Race, Simote Foliaki, Tina Thomas

Emerg Infect Dis· June 2024

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Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model.
Katie Williams, Simote T Foliaki, Brent Race, Anna Smith, Tina Thomas

Stem Cell Res Ther· December 2023

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A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways.
Bradley R Groveman, Benjamin Schwarz, Eric Bohrnsen, Simote T Foliaki, James A Carroll

J Biol Chem· November 2023

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Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots.
Simote T Foliaki, Cathryn L Haigh

PLoS Pathog· October 2023

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Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein.
Simote T Foliaki, Aleksandar Wood, Katie Williams, Anna Smith, Ryan O Walters

Redox Biol· July 2023

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Sporadic Creutzfeldt-Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice.
Bradley R Groveman, Brent Race, Simote T Foliaki, Katie Williams, Andrew G Hughson

Acta Neuropathol Commun· February 2023

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Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction.
Simote T Foliaki, Anna Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M Bosio

PLoS Genet· January 2023

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Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids.
Anna Smith, Bradley R Groveman, Clayton Winkler, Katie Williams, Ryan Walters, Simote T Foliaki

PLoS One· November 2022

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Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function.
Aleksandar R Wood, Simote T Foliaki, Bradley R Groveman, Ryan O Walters, Katie Williams

Sci Rep· September 2022

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Reduced SOD2 expression does not influence prion disease course or pathology in mice.
Simote T Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R Groveman

PLoS One· January 2022

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Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.
Simote T Foliaki, Benjamin Schwarz, Bradley R Groveman, Ryan O Walters, Natalia C Ferreira

Mol Brain· October 2021

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A 3D cell culture approach for studying neuroinflammation.
James A Carroll, Simote T Foliaki, Cathryn L Haigh

J Neurosci Methods· July 2021

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Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt-Jakob disease.
Bradley R Groveman, Natalia C Ferreira, Simote T Foliaki, Ryan O Walters, Clayton W Winkler

Sci Rep· March 2021

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PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity.
Simote T Foliaki, Victoria Lewis, Abu M T Islam, Matteo Senesi, David I Finkelstein

Biophys J· July 2020

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Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease.
Simote T Foliaki, Bradley R Groveman, Jue Yuan, Ryan Walters, Shulin Zhang

Pathogens· June 2020

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Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease.
Scott Ayton, Peng Lei, Ambili T Appukuttan, Thibault Renoir, Simote Foliaki

Neurotherapeutics· January 2020

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Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.
Bradley R Groveman, Simote T Foliaki, Christina D Orru, Gianluigi Zanusso, James A Carroll

Acta Neuropathol Commun· June 2019

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Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc.
Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi

PLoS Pathog· April 2019

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Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer.
Adrian P Wiegmans, Jodi M Saunus, Sunyoung Ham, Richard Lobb, Jamie R Kutasovic, Simote T Foliaki

JCI Insight· February 2019

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Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species.
Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman

PLoS Pathog· August 2018

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