Publications by authors named "Andrew Marks"

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L-Type Ca1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines.
Eleonora Torre, Mélanie Faure, Isabelle Bidaud, Matthias Baudot, Marvin Gaillardon, Andrew R Marks

Circ Res· December 2025

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Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation.
Gunnar Weninger, Haikel Dridi, Steven Reiken, Qi Yuan, Nan Zhao, Andrew R Marks

J Clin Invest· December 2025

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RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data.
Alexander Chang, Halil Beqaj, Leah Sittenfeld, Marco C Miotto, Haikel Dridi, Andrew R Marks

Circ Arrhythm Electrophysiol· September 2025

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Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review.
Gabriel Redel-Traub, Steven O Marx, Andrew R Marks

Circulation· September 2025

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Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders.
Marco C Miotto, Estefania Luna-Figueroa, Carl Tchagou, Laith Bahlouli, Steven Reiken, Andrew R Marks

Proc Natl Acad Sci U S A· June 2025

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Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel.
Kelly Godbout, Mathieu Dugas, Steven R Reiken, Sina Ramezani, Alexia Falle, Andrew R Marks

Int J Mol Sci· March 2025

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Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene.
Kookjoo Kim, Huan Li, Qi Yuan, Zephan Melville, Ran Zalk, Andrew R Marks

bioRxiv· October 2024

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Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Marco C Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi, Andrew R Marks

Nat Commun· September 2024

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Structural insights into the regulation of RyR1 by S100A1.
Gunnar Weninger, Marco C Miotto, Carl Tchagou, Steven Reiken, Haikel Dridi, Andrew R Marks

Proc Natl Acad Sci U S A· July 2024

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Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy.
Monia Souidi, Jessica Resta, Haikel Dridi, Yvonne Sleiman, Steve Reiken, Andrew R Marks

J Cachexia Sarcopenia Muscle· April 2024

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Location of ryanodine receptor type 2 mutation predicts age of onset of sudden death in catecholaminergic polymorphic ventricular tachycardia - A systematic review and meta-analysis of case-based literature.
Halil Beqaj, Leah Sittenfeld, Alexander Chang, Marco Miotto, Haikel Dridi, Andrew R Marks

medRxiv· March 2024

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Rycal S48168 (ARM210) for -related myopathies: a phase one, open-label, dose-escalation trial.
Joshua J Todd, Tokunbor A Lawal, Irene C Chrismer, Angela Kokkinis, Christopher Grunseich, Andrew R Marks

EClinicalMedicine· February 2024

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Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilation.
Haikel Dridi, Marc Yehya, Robert Barsotti, Yang Liu, Steven Reiken, Andrew R Marks

PNAS Nexus· November 2023

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Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes.
Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R Sittenfeld, Andrew R Marks

Stem Cell Res Ther· September 2023

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Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.
Yang Liu, Steven Reiken, Haikel Dridi, Qi Yuan, Khalid S Mohammad, Andrew R Marks

Sci Transl Med· September 2023

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Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.
Haikel Dridi, Gaetano Santulli, Laith Bahlouli, Marco C Miotto, Gunnar Weninger, Andrew R Marks

Biomolecules· September 2023

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Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium 'leak' in tremor pathophysiology.
Regina T Martuscello, Meng-Ling Chen, Steven Reiken, Leah R Sittenfeld, David S Ruff, Andrew R Marks

Acta Neuropathol· August 2023

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Heart failure-induced cognitive dysfunction is mediated by intracellular Ca leak through ryanodine receptor type 2.
Haikel Dridi, Yang Liu, Steven Reiken, Xiaoping Liu, Elentina K Argyrousi, Andrew R Marks

Nat Neurosci· August 2023

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Zoledronic acid improves bone quality and muscle function in a high bone turnover state.
Trupti Trivedi, Mohamed Manaa, Sutha John, Steven Reiken, Sreemala Murthy, Andrew R Marks

bioRxiv· June 2023

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Targeting ryanodine receptors to treat human diseases.
Andrew R Marks

J Clin Invest· January 2023

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Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.
Marissa J Stutzman, C S John Kim, David J Tester, Samantha K Hamrick, Steven M Dotzler, Andrew R Marks

Stem Cell Reports· September 2022

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A drug and ATP binding site in type 1 ryanodine receptor.
Zephan Melville, Haikel Dridi, Qi Yuan, Steven Reiken, Anetta Wronska, Andrew R Marks

Structure· July 2022

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Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on "Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations".
Marco C Miotto, Andrew R Marks

Cell Calcium· July 2022

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Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Marco C Miotto, Gunnar Weninger, Haikel Dridi, Qi Yuan, Yang Liu, Andrew R Marks

Sci Adv· July 2022

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Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in .
Haikel Dridi, Frances Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken, Andrew Marks

Elife· May 2022

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