Publications by authors named "Andrew Mortlock"

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Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples.
Barrett Nuttall, Daniel L Karl, Kathleen Burke, Megan Callahan, Kerrin Mendler, Andrew Mortlock

Clin Epigenetics· October 2025

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Molecular Profiling Identifies CD49d and CD79b as Predictive Markers for Acquired Acalabrutinib Resistance in Patients With Chronic Lymphocytic Leukemia.
Elena Bibikova, Sara Parsa, Muskan Floren, Brian Law, Tracy Clevenger, Andrew Mortlock

Hematol Oncol· January 2025

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Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment.
Mark Roschewski, Manish R Patel, Patrick M Reagan, Nakhle S Saba, Graham P Collins, Andrew Mortlock

Clin Cancer Res· September 2023

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A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer.
Vladimir Lazar, Eitan Rubin, Stephane Depil, Yudi Pawitan, Jean-François Martini, Andrew Mortlock

Oncotarget· June 2015

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Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.
Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T Barry, Darren A E Cross, Andrew A Mortlock

Bioorg Med Chem Lett· June 2012

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Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 1.
Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T Barry, Darren A E Cross, Andrew A Mortlock

Bioorg Med Chem Lett· June 2012

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Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.
Robert H Bradbury, Neil J Hales, Alfred A Rabow, Graeme E Walker, David G Acton, Andrew A Mortlock

Bioorg Med Chem Lett· September 2011

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Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines.
Catherine Bardelle, Tanya Coleman, Darren Cross, Sara Davenport, Jason G Kettle, Andrew Mortlock

Bioorg Med Chem Lett· November 2008

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Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.
Catherine Bardelle, Darren Cross, Sara Davenport, Jason G Kettle, Eun Jung Ko, Andrew Mortlock

Bioorg Med Chem Lett· May 2008

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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.
Kevin M Foote, Andrew A Mortlock, Nicola M Heron, Frédéric H Jung, George B Hill

Bioorg Med Chem Lett· March 2008

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AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Robert W Wilkinson, Rajesh Odedra, Simon P Heaton, Stephen R Wedge, Nicholas J Keen, Andrew A Mortlock

Clin Cancer Res· June 2007

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Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
Andrew A Mortlock, Kevin M Foote, Nicola M Heron, Frédéric H Jung, Georges Pasquet

J Med Chem· May 2007

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SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.
Nicola M Heron, Malcolm Anderson, David P Blowers, Jason Breed, Jonathan M Eden, Andrew A Mortlock

Bioorg Med Chem Lett· March 2006

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Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.
Frédéric H Jung, Georges Pasquet, Christine Lambert-van der Brempt, Jean-Jacques M Lohmann, Nicolas Warin, Andrew A Mortlock

J Med Chem· February 2006

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Progress in the development of selective inhibitors of aurora kinases.
Andrew A Mortlock, Nicholas J Keen, Frederic H Jung, Nicola M Heron, Kevin M Foote

Curr Top Med Chem· October 2005

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Progress in the development of selective inhibitors of Aurora kinases.
Andrew Mortlock, Nicholas J Keen, Frederic H Jung, Nicola M Heron, Kevin M Foote

Curr Top Med Chem· June 2005

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.
Claire Ditchfield, Victoria L Johnson, Anthony Tighe, Rebecca Ellston, Carolyn Haworth, Andrew Mortlock

J Cell Biol· April 2003

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Total Syntheses of (-)-Papuamine and (-)-Haliclonadiamine.
Todd S. McDermott, Andrew A. Mortlock, Clayton H. Heathcock

J Org Chem· January 1996

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