Publications by authors named "Andrew R Leach"

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Temporal trends in evidence supporting novel drug target discovery.
Maria J Falaguera, Ellen M McDonagh, David Ochoa, Polina V Rusina, Juan Maria Roldan-Romero, Andrew R Leach

Nat Commun· December 2025

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Leveraging large-scale biobanks for therapeutic target discovery.
Brian R Ferolito, Hesam Dashti, Claudia Giambartolomei, Gina M Peloso, Daniel J Golden, Andrew R Leach

HGG Adv· December 2025

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Correction to "Pseudonatural Products for Chemical Biology and Drug Discovery".
Luca C Greiner, Axel Pahl, A Lina Heinzke, Barbara Zdrazil, Andrew R Leach

J Med Chem· November 2025

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ChEBI: re-engineered for a sustainable future.
Adnan Malik, Muhammad Arsalan, Carlos Moreno, Juan Mosquera, Eloy Félix, Andrew R Leach

Nucleic Acids Res· November 2025

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EnsembleFlex: Protein structure ensemble analysis made easy.
Melanie Schneider, José Antonio Marquez, Andrew R Leach

Structure· October 2025

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Drug and Clinical Candidate Drug Data in ChEMBL.
Fiona M I Hunter, Harris Ioannidis, A Patrícia Bento, Nicolas Bosc, Sybilla Corbett, Andrew R Leach

J Med Chem· October 2025

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Pseudonatural Products for Chemical Biology and Drug Discovery.
Luca C Greiner, Axel Pahl, A Lina Heinzke, Barbara Zdrazil, Andrew R Leach

J Med Chem· July 2025

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Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction.
Danielle Rasooly, Claudia Giambartolomei, Gina M Peloso, Hesam Dashti, Brian R Ferolito, Andrew R Leach

Nat Cardiovasc Res· March 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Andrew R Leach

RSC Med Chem· February 2025

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EMBL's European Bioinformatics Institute (EMBL-EBI) in 2024.
Matthew Thakur, Catherine Brooksbank, Robert D Finn, Helen V Firth, Julia Foreman, Andrew R Leach

Nucleic Acids Res· January 2025

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A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds.
A Lina Heinzke, Barbara Zdrazil, Paul D Leeson, Robert J Young, Axel Pahl, Andrew R Leach

Sci Data· October 2024

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Occurrence of "Natural Selection" in Successful Small Molecule Drug Discovery.
A Lina Heinzke, Axel Pahl, Barbara Zdrazil, Andrew R Leach, Herbert Waldmann

J Med Chem· July 2024

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A data science roadmap for open science organizations engaged in early-stage drug discovery.
Kristina Edfeldt, Aled M Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, Andrew R Leach

Nat Commun· July 2024

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Overview of the Knowledge Management Center for Illuminating the Druggable Genome.
Tudor I Oprea, Cristian Bologa, Jayme Holmes, Stephen Mathias, Vincent T Metzger, Andrew R Leach

Drug Discov Today· March 2024

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The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods.
Barbara Zdrazil, Eloy Felix, Fiona Hunter, Emma J Manners, James Blackshaw, Andrew R Leach

Nucleic Acids Res· January 2024

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EMBL's European Bioinformatics Institute (EMBL-EBI) in 2023.
Matthew Thakur, Annalisa Buniello, Catherine Brooksbank, Kim T Gurwitz, Matthew Hall, Andrew R Leach

Nucleic Acids Res· January 2024

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Editorial overview: Restructuring drug design and development.
Andrew R Leach, Alison E Ondrus

Curr Opin Struct Biol· December 2023

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MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity.
Nicolas Bosc, Eloy Felix, J Mark F Gardner, James Mills, Martijn Timmerman, Andrew R Leach

ACS Med Chem Lett· December 2023

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Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity.
Clare E West, Mohd Karim, Maria J Falaguera, Leo Speidel, Charlotte J Green, Andrew R Leach

Sci Data· September 2023

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eTRANSAFE: data science to empower translational safety assessment.
Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Shoji Asakura, Andrew R Leach

Nat Rev Drug Discov· August 2023

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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.
Danielle Rasooly, Gina M Peloso, Alexandre C Pereira, Hesam Dashti, Claudia Giambartolomei, Andrew R Leach

Nat Commun· July 2023

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Illuminating the druggable genome through patent bioactivity data.
Maria P Magariños, Anna Gaulton, Eloy Félix, Tevfik Kiziloren, Ricardo Arcila, Andrew R Leach

PeerJ· May 2023

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CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Suzanne Ackloo, Rima Al-Awar, Rommie E Amaro, Cheryl H Arrowsmith, Hatylas Azevedo, Andrew R Leach

Nat Rev Chem· April 2022

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Target 2035 - update on the quest for a probe for every protein.
Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Andrew R Leach

RSC Med Chem· January 2022

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Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level.
Hannah C Copley, Loren Gragert, Andrew R Leach, Vasilis Kosmoliaptsis

Front Immunol· August 2021

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