Publications by authors named "Andrew Racher"

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Directed evolution of biomass intensive CHO cells by adaptation to sub-physiological temperature.
Katie L Syddall, Alejandro Fernandez-Martell, Joseph F Cartwright, Cristina N Alexandru-Crivac, Adam Hodgson, Andrew J Racher

Metab Eng· January 2024

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A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells.
James D Budge, Joanne Roobol, Gurdeep Singh, Théo Mozzanino, Tanya J Knight, Andrew J Racher

Metab Eng Commun· December 2021

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Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production.
James D Budge, Tanya J Knight, Jane Povey, Joanne Roobol, Ian R Brown, Andrew J Racher

Data Brief· April 2020

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Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production.
James D Budge, Tanya J Knight, Jane Povey, Joanne Roobol, Ian R Brown, Andrew J Racher

Metab Eng· January 2020

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Intact-Cell MALDI-ToF Mass Spectrometry for the Authentication of Drug-Adapted Cancer Cell Lines.
Jane F Povey, Emily Saintas, Adewale V Aderemi, Florian Rothweiler, Richard Zehner, Andrew J Racher

Cells· October 2019

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Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions.
Maximilian Lularevic, Andrew J Racher, Colin Jaques, Alexandros Kiparissides

Biotechnol Bioeng· September 2019

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Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development.
Kyle Zingaro, David Shaw, Jerry Carson, Anke Mayer-Bartschmid, Christian Bender, Andrew J Racher

PDA J Pharm Sci Technol· May 2019

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Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors.
Ruth C Rowland-Jones, Frans van den Berg, Andrew J Racher, Elaine B Martin, Colin Jaques

Biotechnol Prog· March 2017

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Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.
Marc Feary, Andrew J Racher, Robert J Young, C Mark Smales

Biotechnol Prog· January 2017

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Diversity in host clone performance within a Chinese hamster ovary cell line.
Peter M O'Callaghan, Maud E Berthelot, Robert J Young, James W A Graham, Andrew J Racher

Biotechnol Prog· August 2016

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Does earlier use of productivity enhancers during cell line selection lead to the identification of more productive cell lines?
Alison J Porter, Atul Mohindra, Juana Maria Porter, Andrew J Racher

BMC Proc· April 2015

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Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling.
Jane F Povey, Christopher J O'Malley, Tracy Root, Elaine B Martin, Gary A Montague, Andrew J Racher

J Biotechnol· August 2014

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Functional heterogeneity and heritability in CHO cell populations.
Sarah L Davies, Clare S Lovelady, Rhian K Grainger, Andrew J Racher, Robert J Young

Biotechnol Bioeng· January 2013

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Impact of gene vector design on the control of recombinant monoclonal antibody production by Chinese hamster ovary cells.
Sarah L Davies, Peter M O'Callaghan, Jane McLeod, Leon P Pybus, Yun Hee Sung, Andrew J Racher

Biotechnol Prog· March 2012

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An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.
Jane McLeod, Peter M O'Callaghan, Leon P Pybus, Stephen J Wilkinson, Tracy Root, Andrew J Racher

Biotechnol Bioeng· September 2011

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Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: realizing the potential in bioreactors.
Alison J Porter, Alan J Dickson, Andrew J Racher

Biotechnol Prog· January 2011

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Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: improving the efficiency of cell line generation.
Alison J Porter, Andrew J Racher, Richard Preziosi, Alan J Dickson

Biotechnol Prog· January 2011

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Cell line-specific control of recombinant monoclonal antibody production by CHO cells.
Peter M O'Callaghan, Jane McLeod, Leon P Pybus, Clare S Lovelady, Stephen J Wilkinson, Andrew J Racher

Biotechnol Bioeng· August 2010

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Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures.
Rosalyn J Marchant, Mohamed B Al-Fageeh, Michele F Underhill, Andrew J Racher, C Mark Smales

Mol Biotechnol· May 2008

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Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture.
Scott H Stansfield, Emma E Allen, Diane M Dinnis, Andrew J Racher, John R Birch

Biotechnol Bioeng· June 2007

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The role of p21cip1 in adaptation of CHO cells to suspension and protein-free culture.
Kelly Astley, Mariam Naciri, Andrew Racher, Mohamed Al-Rubeai

J Biotechnol· June 2007

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Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.
Diane M Dinnis, Scott H Stansfield, Stefan Schlatter, C Mark Smales, Daniel Alete, Andrew J Racher

Biotechnol Bioeng· August 2006

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Control of culture environment for improved polyethylenimine-mediated transient production of recombinant monoclonal antibodies by CHO cells.
Douglas J Galbraith, Andrew S Tait, Andrew J Racher, John R Birch, David C James

Biotechnol Prog· August 2006

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Antibody production.
John R Birch, Andrew J Racher

Adv Drug Deliv Rev· August 2006

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On the statistical analysis of the GS-NS0 cell proteome: imputation, clustering and variability testing.
Norhaiza Ahmad, Jian Zhang, Phillip J Brown, David C James, John R Birch, Andrew J Racher

Biochim Biophys Acta· July 2006

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