Publications by authors named "Andrew Stephen"

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Cholecystectomy patient characteristics on Acute Care Surgery versus general surgery services.
Tynan H Friend, Madeline Goosman, Adam Aluisio, Brent Emigh, Benjamin Hall, Andrew Stephen

Am J Surg· January 2026

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How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations.
Lin Frank Song, Dana Rabara, Semiha K Bali, Jun Pei, Edmond Y Lau, Andrew G Stephen

J Chem Inf Model· December 2025

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Choice of Machine Learning Models Is Important to Predict Post-Operative Infections in Surgical Patients.
Addison Heffernan, Reetam Ganguli, Isaac Sears, Andrew H Stephen, Daithi S Heffernan

Surg Infect (Larchmt)· September 2025

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An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco, Andrew G Stephen

Proc Natl Acad Sci U S A· September 2025

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Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations.
Timothy S Carpenter, Fikret Aydin, Chris Neale, Que N Van, Xiaohua Zhang, Andrew G Stephen

Biophys J· August 2025

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An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco, Andrew G Stephen

bioRxiv· August 2025

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The Rare Use of Respiratory Protective Equipment by Workers on Prominent Home Improvement Programs.
Andrew H Stephen, Debasree Banerjee

Ann Am Thorac Soc· July 2025

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Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints.
Patrick Alexander, Albert H Chan, Dana Rabara, Monalisa Swain, Erik K Larsen, Andrew G Stephen

J Biol Chem· July 2025

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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.
Dhirendra K Simanshu, Rui Xu, James P Stice, Daniel J Czyzyk, Siyu Feng, Andrew G Stephen

Science· July 2025

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Extra-abdominal CT imaging indicates increased severity of illness in advanced age patients requiring emergency abdominal surgery.
Lavina Malhotra, Andrew H Stephen, Madeline Goosman, Adam R Aluisio, Mohammed Arafeh

Am J Surg· June 2025

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Changing Injury Pattern in Geriatric Admissions in a Level-1 Trauma Center.
Iva Neupane, Joao Filipe G Monteiro, Nadia Mujahid, Andrew Stephen, Stephanie Lueckel

R I Med J (2013)· May 2025

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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.
Anna E Maciag, Yue Yang, Alok K Sharma, David M Turner, Caroline J DeHart, Stephen Fox, Andrew G Stephen

Proc Natl Acad Sci U S A· May 2025

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Perceived Risks, Mitigation Strategies, and Modifiability of Telehealth in Rural and Remote Emergency Departments: Qualitative Exploration Study.
Christina Tsou, Justin Yeung, Melanie Goode, Josephine Mcdonnell, Aled Williams, Stephen Colin Andrew

JMIR Hum Factors· April 2025

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Did Madeline Suffer Complications or was a 10 Plus Day Stay After Appendectomy Unremarkable in 1939?
Andrew H Stephen, Madeline Goosman

J Pediatr Surg· March 2025

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Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.
Anna E Maciag, James P Stice, Bin Wang, Alok K Sharma, Albert H Chan, Andrew G Stephen

Cancer Discov· March 2025

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Perioperative Venous Thromboembolism Prophylaxis in Orthopedic Trauma: A Practical Review.
Brent Emigh, Audrea Bose, Andrew Stephen, Jessica Arabi, Charles Adams

R I Med J (2013)· February 2025

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Implementation of rural provider-to-provider telehealth in country Western Australia: a retrospective observational analysis via the RE-AIM framework.
Kaylie Toll, Suzanne Robinson, Stephen Andrew, Aled Williams, Justin Yeung

BMC Health Serv Res· January 2025

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Two hearts beat as one: the debate over RAS dimers continues.
Andrew G Stephen

Trends Biochem Sci· November 2024

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KRas4b-Calmodulin Interaction with Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics.
Shweta Shree, Mark A McLean, Andrew G Stephen, Stephen G Sligar

Biochemistry· November 2024

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Joint Position Statement on EMS Performance Measures Beyond Response Times.
Douglas F Kupas, Matt Zavadsky, Brooke Burton, Chip Decker, Robert Dunne, Andrew Stephen

Prehosp Emerg Care· October 2024

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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Johannes Morstein, Victoria Bowcut, Micah Fernando, Yue Yang, Lawrence Zhu, Andrew G Stephen

Cell· October 2024

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Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96.
Randa Mahran, Jonas N Kapp, Salla Valtonen, Allison Champagne, Jinying Ning, Andrew G Stephen

ACS Chem Biol· October 2024

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Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Jason J Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Andrew G Stephen

bioRxiv· October 2024

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Azorean Immigrants - The Keelson of Rhode Island Hospital.
Madeline Goosman, Nicole Dagen, Andrew H Stephen

R I Med J (2013)· September 2024

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Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry.
Robert A D'Ippolito, Grace M Scheidemantle, Dana Rabara, Maria Abreu Blanco, Nitya Ramakrishnan, Andrew G Stephen

Methods Mol Biol· July 2024

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