Publications by authors named "Angela Cacace"

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New therapies on the horizon: Targeted protein degradation in neuroscience.
James A Gregory, Christopher M Hickey, Juan Chavez, Angela M Cacace

Cell Chem Biol· September 2024

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Application of induced proximity for therapeutic discovery.
Angela Cacace, Danette Daniels, Fleur M Ferguson, Cristina Mayor-Ruiz, Christina Woo

Cell Chem Biol· June 2024

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Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.
Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Angela Cacace

Mol Neurodegener· June 2024

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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Christopher M Hickey, Katherine M Digianantonio, Kurt Zimmermann, Alicia Harbin, Connor Quinn, Angela M Cacace

Nat Struct Mol Biol· February 2024

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Fragile X Syndrome Patient-Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes.
Marine A Krzisch, Hao Wu, Bingbing Yuan, Troy W Whitfield, X Shawn Liu, Angela Cacace

Biol Psychiatry· January 2023

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Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
Amy Easton, Marianne L Jensen, Congwei Wang, Peter H Hagedorn, Yuwen Li, Angela M Cacace

Mol Ther Nucleic Acids· September 2022

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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.
Peter H Hagedorn, Jeffrey M Brown, Amy Easton, Maria Pierdomenico, Kelli Jones, Angela M Cacace

Nucleic Acid Ther· June 2022

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Current directions in tau research: Highlights from Tau 2020.
Claire Sexton, Heather Snyder, Dirk Beher, Adam L Boxer, Pat Brannelly, Angela M Cacace

Alzheimers Dement· May 2022

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p38 Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy.
L Alejandro Rojas, Erin Valentine, Anthony Accorsi, Joseph Maglio, Ning Shen, Angela M Cacace

J Pharmacol Exp Ther· September 2020

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Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons.
John D Graef, Hao Wu, Carrie Ng, Chicheng Sun, Vivian Villegas, Angela Cacace

Eur J Neurosci· May 2020

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Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.
Brian R Anderson, Marianne L Jensen, Peter H Hagedorn, Sean C Little, Richard E Olson, Angela Cacace

Mol Ther Nucleic Acids· March 2020

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Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.
Sarah C Hopp, Nathan A Bihlmeyer, John P Corradi, Charles Vanderburg, Angela M Cacace

J Neurochem· October 2018

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Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.
X Shawn Liu, Hao Wu, Marine Krzisch, Xuebing Wu, John Graef, Angela Cacace

Cell· February 2018

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Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line.
Lisa Hunihan, Jeffrey Brown, Angela Cacace, Alda Fernandes, Andrea Weston

Stem Cell Res· April 2017

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Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.
Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Angela Cacace

PLoS One· February 2016

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Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.
Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Angela M Cacace

PLoS One· December 2015

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Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.
Martin A Lewis, Lisa Hunihan, John Watson, Robert G Gentles, Shuanghua Hu, Angela M Cacace

J Pharmacol Exp Ther· September 2015

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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Carolyn D Dzierba, Yingzhi Bi, Bireshwar Dasgupta, Richard A Hartz, Vijay Ahuja, Angela Cacace

Bioorg Med Chem Lett· April 2015

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The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Yingzhi Bi, Carolyn D Dzierba, Cynthia Fink, Yudith Garcia, Michael Green, Angela Cacace

Bioorg Med Chem Lett· April 2015

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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Susan E Kiefer, Chiehying J Chang, S Roy Kimura, Mian Gao, Dianlin Xie, Angela M Cacace

Acta Crystallogr F Struct Biol Commun· February 2014

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Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.
Karl Herrup, Maria C Carrillo, Dale Schenk, Angela Cacace, Susan Desanti

Alzheimers Dement· July 2013

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Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
Hannguang Chao, Huji Turdi, Timothy F Herpin, Jacques Y Roberge, Yalei Liu, Angela M Cacace

J Med Chem· February 2013

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The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.
Darrick T Balu, Alo C Basu, John P Corradi, Angela M Cacace, Joseph T Coyle

Neurobiol Dis· February 2012

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Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening.
Mark A Gilchrist, Angela Cacace, David G Harden

J Biomol Screen· July 2008

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A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.
Stephen R Johnson, Ramesh Padmanabha, Wayne Vaccaro, Mark Hermsmeier, Angela Cacace

J Biomol Screen· March 2007

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