Publications by authors named "Dale Schenk"

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Effects of α-Synuclein Immunization in a Mouse Model of Parkinson's Disease.
Eliezer Masliah, Edward Rockenstein, Anthony Adame, Michael Alford, Leslie Crews, Dale Schenk

Neuron· November 2025

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Dale Schenk

Sci Rep· November 2019

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Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk

JAMA Neurol· October 2018

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Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Dale Schenk

Neurology· January 2018

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First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers.
Dale B Schenk, Martin Koller, Daniel K Ness, Sue G Griffith, Michael Grundman

Mov Disord· February 2017

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Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.
Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Dale Schenk

Acta Neuropathol Commun· January 2017

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2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis .
Mark Renz, Ronald Torres, Philip J Dolan, Stephen J Tam, Jose R Tapia, Dale Schenk

Amyloid· September 2016

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Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk

Curr Alzheimer Res· August 2016

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First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction.
Morie A Gertz, Heather Landau, Raymond L Comenzo, David Seldin, Brendan Weiss, Dale B Schenk

J Clin Oncol· April 2016

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Dale Schenk

PLoS One· October 2014

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Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Dale Schenk

J Neurosci· July 2014

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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab.
Hadar Feinberg, José W Saldanha, Linnea Diep, Amita Goel, Angela Widom, Dale Schenk

Alzheimers Res Ther· July 2014

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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.
Shyra J Gardai, Wenxian Mao, Birgitt Schüle, Michael Babcock, Sue Schoebel, Dale B Schenk

PLoS One· June 2014

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β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition.
Adrienne L Orr, Jesse E Hanson, Dong Li, Adam Klotz, Sarah Wright, Dale Schenk

Neuron· June 2014

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Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities.
Wagner Zago, Sally Schroeter, Teresa Guido, Karen Khan, Peter Seubert, Dale Schenk

Alzheimers Dement· October 2013

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Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid β-peptide.
Nicolaas A Verwey, Jeroen J M Hoozemans, Carsten Korth, Marloes R van Royen, Ingrid Prikulis, Dale Schenk

Amyloid· September 2013

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Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.
Karl Herrup, Maria C Carrillo, Dale Schenk, Angela Cacace, Susan Desanti

Alzheimers Dement· July 2013

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Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide.
Maximillian Zhu, Alfonso De Simone, Dale Schenk, Gergely Toth, Christopher M Dobson

J Chem Phys· July 2013

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AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils.
Jonathan S Wall, Stephen J Kennel, Angela Williams, Tina Richey, Alan Stuckey, Dale Schenk

PLoS One· June 2013

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Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.
Dora Games, Peter Seubert, Edward Rockenstein, Christina Patrick, Margarita Trejo, Dale Schenk

Am J Pathol· March 2013

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Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
Sean A Pintchovski, Dale B Schenk, Guriqbal S Basi

Curr Alzheimer Res· January 2013

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Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice.
Frédérique Bard, Michael Fox, Stuart Friedrich, Peter Seubert, Dale Schenk

Exp Neurol· November 2012

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Treatment strategies targeting amyloid β-protein.
Dale Schenk, Guriqbal S Basi, Menelas N Pangalos

Cold Spring Harb Perspect Med· September 2012

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Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.
Mary D Naylor, Jason H Karlawish, Steven E Arnold, Ara S Khachaturian, Zaven S Khachaturian, Dale Schenk

Alzheimers Dement· September 2012

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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.
Wagner Zago, Manuel Buttini, Thomas A Comery, Christopher Nishioka, Shyra J Gardai, Dale Schenk

J Neurosci· February 2012

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