Publications by authors named "Angela Clerk"

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Mitogen-activated protein kinase signalling in rat hearts during postnatal development: MAPKs, MAP3Ks, MAP4Ks and DUSPs.
Hajed O Alharbi, Peter H Sugden, Angela Clerk

Cell Signal· December 2024

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Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.
Joshua J Cull, Susanna T E Cooper, Hajed O Alharbi, Sonia P Chothani, Owen J L Rackham, Angela Clerk

Clin Sci (Lond)· May 2024

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Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
Hajed O Alharbi, Michelle A Hardyman, Joshua J Cull, Thomais Markou, Susanna T E Cooper, Angela Clerk

Clin Sci (Lond)· November 2022

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PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.
Jacqueline J T Marshall, Joshua J Cull, Hajed O Alharbi, May Zaw Thin, Susanna T E Cooper, Angela Clerk

Biochem J· July 2022

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The insulin receptor family in the heart: new light on old insights.
Angela Clerk, Peter H Sugden

Biosci Rep· July 2022

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Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Angela Clerk, Daniel N Meijles, Michelle A Hardyman, Stephen J Fuller, Sonia P Chothani

Biochem J· February 2022

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The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Daniel N Meijles, Joshua J Cull, Susanna T E Cooper, Thomais Markou, Michelle A Hardyman, Angela Clerk

Clin Sci (Lond)· July 2021

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The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
Daniel N Meijles, Stephen J Fuller, Joshua J Cull, Hajed O Alharbi, Susanna T E Cooper, Angela Clerk

Biochem J· June 2021

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MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.
Stephen J Fuller, Nick S Edmunds, Liam J McGuffin, Michelle A Hardyman, Joshua J Cull, Angela Clerk

Biochem J· June 2021

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Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension.
Daniel N Meijles, Joshua J Cull, Thomais Markou, Susanna T E Cooper, Zoe H R Haines, Angela Clerk

Hypertension· October 2020

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The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.
Daniel N Meijles, Georgia Zoumpoulidou, Thomais Markou, Kerry A Rostron, Rishi Patel, Angela Clerk

J Mol Cell Cardiol· April 2019

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Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.
Stephen J Fuller, Sally A Osborne, Sam J Leonard, Michelle A Hardyman, George Vaniotis, Angela Clerk

Cardiovasc Res· October 2015

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ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.
Adelino F Leite-Moreira, André P Lourenço, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk

Eur J Heart Fail· May 2014

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Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.
Guido Tarone, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon De Windt

Eur J Heart Fail· May 2014

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Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation.
Marcus J Tindall, Angela Clerk

PLoS Comput Biol· May 2014

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.
Peter H Sugden, Liam J McGuffin, Angela Clerk

Biochem J· August 2013

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p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.
Emre Amirak, Stephen J Fuller, Peter H Sugden, Angela Clerk

Biochem J· March 2013

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The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.
Oliver P T Barrett, Arne Yndestad, Andrew K Marshall, Peter H Sugden, Angela Clerk

Cytokine· February 2013

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Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target.
Alejandro Giraldo, Oliver P T Barrett, Marcus J Tindall, Stephen J Fuller, Emre Amirak, Angela Clerk

Biochem J· June 2012

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A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Stephen J Fuller, Liam J McGuffin, Andrew K Marshall, Alejandro Giraldo, Sampsa Pikkarainen, Angela Clerk

Biochem J· March 2012

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Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.
Peter H Sugden, Thomais Markou, Stephen J Fuller, El Li Tham, Jeffery D Molkentin, Angela Clerk

Cell Signal· February 2011

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Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.
Thomais Markou, Andrew K Marshall, Timothy E Cullingford, El L Tham, Peter H Sugden, Angela Clerk

BMC Genomics· May 2010

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ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
Andrew K Marshall, Oliver P T Barrett, Timothy E Cullingford, Achchuthan Shanmugasundram, Peter H Sugden, Angela Clerk

PLoS One· April 2010

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Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.
Arne Yndestad, Andrew K Marshall, Jonathan D Hodgkinson, El Li Tham, Peter H Sugden, Angela Clerk

Int J Biochem Cell Biol· February 2010

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Dying by the way you live: AIF vs. caspases in apoptosis of hypertrophied cardiomyocytes.
Angela Clerk, Peter H Sugden

Cardiovasc Res· January 2010

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