Publications by authors named "Angelica Merlot"

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Surface Proteomic Analysis Reveals the Presence of Noncanonical Cell Membrane Endoplasmic Reticulum Chaperones in High-Grade Gliomas.
Alexis Z Minchaca, Jean Bertoldo, Philipp Graber, Dong-Hun Bae, Nisitha Jayatilleke, Angelica M Merlot

J Proteome Res· November 2025

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Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer.
Georgia Porter, Murray D Norris, Minoti Apte, Angelica M Merlot

Neoplasia· February 2025

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Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.
Angelica M Merlot, Danuta S Kalinowski, Zaklina Kovacevic, Patric J Jansson, Sumit Sahni

Curr Med Chem· April 2019

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Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".
Angelica M Merlot, Sumit Sahni, Darius J R Lane, Vera Richardson, Michael L H Huang

Int J Mol Sci· November 2016

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Angelica M Merlot

Autophagy· October 2016

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Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
Elaine M Gutierrez, Nicole A Seebacher, Laila Arzuman, Zaklina Kovacevic, Darius J R Lane, Angelica M Merlot

Biochim Biophys Acta· July 2016

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Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
Angelica M Merlot, Nurul H Shafie, Yu Yu, Vera Richardson, Patric J Jansson

Biochem Pharmacol· June 2016

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Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia.
Shannon Chiang, Zaklina Kovacevic, Sumit Sahni, Darius J R Lane, Angelica M Merlot

Clin Sci (Lond)· June 2016

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Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.
Danuta S Kalinowski, Christian Stefani, Shinya Toyokuni, Tomas Ganz, Gregory J Anderson, Angelica M Merlot

Biochim Biophys Acta· April 2016

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Making a case for albumin – a highly promising drug-delivery system.
Angelica M Merlot, Danuta S Kalinowski, Zaklina Kovacevic, Patric J Jansson, Darius J R Lane

Future Med Chem· January 2016

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The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.
Wensheng Liu, Zaklina Kovacevic, Zhihai Peng, Runsen Jin, Puxiongzhi Wang, Angelica M Merlot

Oncotarget· November 2015

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The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.
Patric J Jansson, Danuta S Kalinowski, Darius J R Lane, Zaklina Kovacevic, Nicole A Seebacher, Angelica M Merlot

Pharmacol Res· October 2015

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Targeting cancer by binding iron: Dissecting cellular signaling pathways.
Goldie Y L Lui, Zaklina Kovacevic, Vera Richardson, Angelica M Merlot, Danuta S Kalinowski

Oncotarget· August 2015

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Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.
Angelica M Merlot, Sumit Sahni, Darius J R Lane, Ashleigh M Fordham, Namfon Pantarat

Oncotarget· April 2015

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The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.
Wensheng Liu, Fei Yue, Minhua Zheng, Angelica Merlot, Dong-Hun Bae

Oncotarget· April 2015

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Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.
Goldie Y L Lui, Zaklina Kovacevic, Sharleen V Menezes, Danuta S Kalinowski, Angelica M Merlot

Mol Pharmacol· March 2015

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Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.
Darius J R Lane, Dong-Hun Bae, Angelica M Merlot, Sumit Sahni, Des R Richardson

Nutrients· March 2015

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Gene of the month: BECN1.
Sumit Sahni, Angelica M Merlot, Sukriti Krishan, Patric J Jansson, Des R Richardson

J Clin Pathol· August 2014

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Unraveling the mysteries of serum albumin-more than just a serum protein.
Angelica M Merlot, Danuta S Kalinowski, Des R Richardson

Front Physiol· August 2014

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Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.
Darius J R Lane, Thomas M Mills, Nurul H Shafie, Angelica M Merlot, Rayan Saleh Moussa

Biochim Biophys Acta· April 2014

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Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.
Angelica M Merlot, Namfon Pantarat, Sharleen V Menezes, Sumit Sahni, Des R Richardson

Mol Pharmacol· December 2013

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Novel chelators for cancer treatment: where are we now?
Angelica M Merlot, Danuta S Kalinowski, Des R Richardson

Antioxid Redox Signal· March 2013

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Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
Maciej Serda, Danuta S Kalinowski, Anna Mrozek-Wilczkiewicz, Robert Musiol, Agnieszka Szurko, Angelica M Merlot

Bioorg Med Chem Lett· September 2012

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Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer.
Angelica M Merlot, Namfon Pantarat, David B Lovejoy, Danuta S Kalinowski, Des R Richardson

Mol Pharmacol· October 2010

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