Publications by authors named "Angus Sinclair"

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IGM-7354, an Immunocytokine with IL15 Fused to an Anti-PD-L1 IgM, Induces NK and CD8+ T cell-Mediated Cytotoxicity of PD-L1-Positive Tumor Cells.
Mélanie Desbois, Thierry Giffon, Poonam Yakkundi, Carolyn R Denson, Keerthana Sekar, Angus M Sinclair

Cancer Immunol Res· August 2025

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Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199.
Beatrice T Wang, Tasnim Kothambawala, Ling Wang, Thomas J Matthew, Susan E Calhoun, Angus M Sinclair

Mol Cancer Ther· December 2021

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Structure, Function, and Therapeutic Use of IgM Antibodies.
Bruce A Keyt, Ramesh Baliga, Angus M Sinclair, Stephen F Carroll, Marvin S Peterson

Antibodies (Basel)· October 2020

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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Swetha Raman, Melissa Beilschmidt, Minh To, Kevin Lin, Francine Lui, Angus M Sinclair

Proc Natl Acad Sci U S A· April 2019

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The Broad Anti-AML Activity of the CD33/CD3 BiTE Antibody Construct, AMG 330, Is Impacted by Disease Stage and Risk.
Kimberly H Harrington, Chelsea J Gudgeon, George S Laszlo, Kathryn J Newhall, Angus M Sinclair

PLoS One· May 2016

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A Comparison of the Efficacy and Adverse Effects of Double-Lumen Endobronchial Tubes and Bronchial Blockers in Thoracic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Ana Clayton-Smith, Kyle Bennett, Robin Peter Alston, George Adams, Greg Brown, Angus Sinclair

J Cardiothorac Vasc Anesth· August 2015

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Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia.
Patricia L McElroy, Ping Wei, Keri Buck, Angus M Sinclair, Michael Eschenberg

Exp Hematol· June 2015

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Characterization of bispecific T-cell Engager (BiTE) antibodies with a high-capacity T-cell dependent cellular cytotoxicity (TDCC) assay.
Aaron A Nazarian, Ivonne L Archibeque, Yen H Nguyen, Paul Wang, Angus M Sinclair

J Biomol Screen· April 2015

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AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia.
Cong Li, Liqin Liu, Lingming Liang, Zhen Xia, Zhihong Li, Angus Sinclair

Mol Cancer Ther· February 2015

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Dose-related differences in the pharmacodynamic and toxicologic response to a novel hyperglycosylated analog of recombinant human erythropoietin in Sprague-Dawley rats with similarly high hematocrit.
Dina A Andrews, Babette M Boren, James R Turk, Rogely W Boyce, Yudong D He, Angus M Sinclair

Toxicol Pathol· December 2014

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Cytokines associated with increased erythropoiesis in Sprague-Dawley rats administered a novel hyperglycosylated analog of recombinant human erythropoietin.
Dina A Andrews, Hisham K Hamadeh, Yudong D He, Babette M Boren, James R Turk, Angus M Sinclair

Toxicol Pathol· December 2014

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Progress in detecting cell-surface protein receptors: the erythropoietin receptor example.
Steve Elliott, Angus Sinclair, Helen Collins, Linda Rice, Wolfgang Jelkmann

Ann Hematol· February 2014

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Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML.
George S Laszlo, Chelsea J Gudgeon, Kimberly H Harrington, Justine Dell'Aringa, Kathryn J Newhall, Angus M Sinclair

Blood· January 2014

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Erythropoiesis stimulating agents: approaches to modulate activity.
Angus M Sinclair

Biologics· July 2013

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The effect of erythropoietin on normal and neoplastic cells.
Steve Elliott, Angus M Sinclair

Biologics· October 2012

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Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells.
Angus M Sinclair, Angela Coxon, Ian McCaffery, Stephen Kaufman, Katherine Paweletz

Blood· May 2010

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Absence of functional EpoR expression in human tumor cell lines.
Susan Swift, Aaron R Ellison, Paul Kassner, Ian McCaffery, John Rossi, Angus M Sinclair

Blood· May 2010

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Erythropoietin receptor in ovarian cancer cells - Letter.
Susan E Swift, Steve Elliott, Angus M Sinclair, C Glenn Begley

Mol Cancer Ther· April 2010

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Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells.
Steve Elliott, Leigh Busse, Ian McCaffery, John Rossi, Angus Sinclair

J Immunol Methods· January 2010

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Optimization and utilization of the SureFire phospho-STAT5 assay for a cell-based screening campaign.
Christina Binder, Amy Lafayette, Ivonne Archibeque, Yu Sun, Cherylene Plewa, Angus Sinclair

Assay Drug Dev Technol· February 2008

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Expression and function of erythropoietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients.
Angus M Sinclair, Marque D Todd, Kevin Forsythe, Susan J Knox, Steve Elliott

Cancer· August 2007

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Anti-Epo receptor antibodies do not predict Epo receptor expression.
Steve Elliott, Leigh Busse, Michael B Bass, Hsieng Lu, Ildiko Sarosi, Angus M Sinclair

Blood· March 2006

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Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins.
Angus M Sinclair, Steve Elliott

J Pharm Sci· August 2005

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Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.
Thomas Hiesberger, Yun Bai, Xinli Shao, Brian T McNally, Angus M Sinclair

J Clin Invest· March 2004

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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
Fangming Lin, Thomas Hiesberger, Kimberly Cordes, Angus M Sinclair, Lawrence S B Goldstein

Proc Natl Acad Sci U S A· April 2003

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