Publications by authors named "Ann Arfsten"

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Hepatitis C genotype 1a replicon improved through introduction of fitness mutations.
Christian Voitenleitner, Jill Bechtel, Ann Arfsten, Robert Hamatake

Biotechniques· April 2012

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Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution.
Sharlene R Lim, Xiaoli Qin, Simone Susser, John B Nicholas, Christian Lange, Ann Arfsten

Antimicrob Agents Chemother· January 2012

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Design, synthesis and discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as highly potent factor Xa inhibitors.
Zhaozhong Jon Jia, Robert Murry Scarborough, Penglie Zhang, Sherin Halfon, Ann Elizabeth Arfsten

Chem Pharm Bull (Tokyo)· September 2009

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Penglie Zhang, Wenrong Huang, Lingyan Wang, Liang Bao, Zhaozhong J Jia, Ann E Arfsten

Bioorg Med Chem Lett· April 2009

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Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors.
Shawn M Bauer, Erick A Goldman, Wenrong Huang, Ting Su, Lingyan Wang, Ann Arfsten

Bioorg Med Chem Lett· August 2004

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N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors.
Zhaozhong J Jia, Ting Su, Jingmei F Zuckett, Yanhong Wu, Erick A Goldman, Ann E Arfsten

Bioorg Med Chem Lett· May 2004

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs.
Zhaozhong J Jia, Yanhong Wu, Wenrong Huang, Penglie Zhang, Lane A Clizbe, Ann E Arfsten

Bioorg Med Chem Lett· March 2004

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.
Zhaozhong J Jia, Yanhong Wu, Wenrong Huang, Penglie Zhang, Yonghong Song, Ann E Arfsten

Bioorg Med Chem Lett· March 2004

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs.
Penglie Zhang, Liang Bao, Jingmei F Zuckett, Erick A Goldman, Zhaozhong J Jia, Ann Arfsten

Bioorg Med Chem Lett· February 2004

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.
Penglie Zhang, Liang Bao, Jingmei F Zuckett, Zhaozhong J Jia, John Woolfrey, Ann Arfsten

Bioorg Med Chem Lett· February 2004

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Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.
Uma Sinha, Pei Hua Lin, Susan T Edwards, Paul W Wong, Bingyan Zhu, Ann E Arfsten

Arterioscler Thromb Vasc Biol· June 2003

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Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Wenrong Huang, Mary Ann Naughton, Hua Yang, Ting Su, Suiko Dam, Ann Arfsten

Bioorg Med Chem Lett· February 2003

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