Publications by authors named "Anne H Dantzig"

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Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.
Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Gregory P Donoho, James J Starling, Anne H Dantzig

Mol Cancer Ther· April 2013

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Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
Jessica A Roseberry Baker, Enaksha R Wickremsinhe, Claire H Li, Olukayode A Oluyedun, Anne H Dantzig

Drug Metab Dispos· March 2013

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Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.
Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Kathleen Heinz-Taheny, Philip W Iversen, Anne H Dantzig

Clin Cancer Res· March 2013

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Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis.
Giulio Francia, Yuval Shaked, Kae Hashimoto, John Sun, Melissa Yin, Anne H Dantzig

Mol Cancer Ther· March 2012

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Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
David M Bender, Jingqi Bao, Anne H Dantzig, William D Diseroad, Kevin L Law

J Med Chem· November 2009

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Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.
Susan Pratt, Victor Chen, William I Perry, James J Starling, Anne H Dantzig

Eur J Pharm Sci· April 2006

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Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).
Bryan H Norman, Peter A Lander, Joseph M Gruber, Julian S Kroin, Jeffrey D Cohen, Anne H Dantzig

Bioorg Med Chem Lett· December 2005

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Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
William L Perry, Robert L Shepard, Janardhan Sampath, Benjamin Yaden, William W Chin, Anne H Dantzig

Cancer Res· August 2005

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Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
Ana Belén Bueno, Iván Collado, Alfonso de Dios, Carmen Domínguez, José Alfredo Martín, Anne H Dantzig

J Med Chem· August 2005

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The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Susan Pratt, Robert L Shepard, Ramani A Kandasamy, Paul A Johnston, William Perry, Anne H Dantzig

Mol Cancer Ther· May 2005

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Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin.
Isabel Behrens, Walter Kamm, Anne H Dantzig, Thomas Kissel

J Pharm Sci· July 2004

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Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Anne H Dantzig, Robert L Shepard, Susan E Pratt, Linda B Tabas, Peter A Lander

Biochem Pharmacol· March 2004

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Characterization and application of a vinblastine-selected CACO-2 cell line for evaluation of p-glycoprotein.
Dennis A Laska, Jack O Houchins, Susan E Pratt, Jeffery Horn, Xialong Xia, Anne H Dantzig

In Vitro Cell Dev Biol Anim· January 2004

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Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.
Janardhan Sampath, Pandy R Long, Robert L Shepard, Xiaoling Xia, Viswanath Devanarayan, Anne H Dantzig

Am J Pathol· November 2003

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Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey.
Nathalie Godinot, Philip W Iversen, Linda Tabas, Xiaoling Xia, Daniel C Williams, Anne H Dantzig

Mol Cancer Ther· March 2003

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Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.
Robert L Shepard, Jin Cao, James J Starling, Anne H Dantzig

Int J Cancer· January 2003

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Considerations in the design and development of transport inhibitors as adjuncts to drug therapy.
Anne H Dantzig, Dinesh P de Alwis, Michael Burgess

Adv Drug Deliv Rev· January 2003

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Identification and characterization of the canine multidrug resistance-associated protein.
Liandong Ma, Susan E Pratt, Jin Cao, Anne H Dantzig, Robert E Moore

Mol Cancer Ther· December 2002

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A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.
Linda B Tabas, Anne H Dantzig

Anal Biochem· November 2002

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Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.
Yue-Ming Qian, Caroline E Grant, Christopher J Westlake, Da-Wei Zhang, Peter A Lander, Anne H Dantzig

J Biol Chem· September 2002

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GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.
Qingcheng Mao, Wei Qiu, Kevin E Weigl, Peter A Lander, Linda B Tabas, Anne H Dantzig

J Biol Chem· August 2002

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Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Sean Ekins, Richard B Kim, Brenda F Leake, Anne H Dantzig, Erin G Schuetz

Mol Pharmacol· May 2002

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Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Sean Ekins, Richard B Kim, Brenda F Leake, Anne H Dantzig, Erin G Schuetz

Mol Pharmacol· May 2002

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Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Bryan H Norman, Joseph M Gruber, Sean P Hollinshead, Joseph W Wilson, James J Starling, Anne H Dantzig

Bioorg Med Chem Lett· March 2002

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A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells.
Yi Hu, Andrew G Stephen, Jin Cao, Lee R Tanzer, Christopher A Slapak, Anne H Dantzig

Int J Cancer· January 2002

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