Publications by authors named "Robert L Shepard"

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Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells.
Bo Tan, Sucai Dong, Robert L Shepard, Lisa Kays, Kenneth D Roth

J Biol Chem· June 2015

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Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.
Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Gregory P Donoho, James J Starling

Mol Cancer Ther· April 2013

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Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.
Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Kathleen Heinz-Taheny, Philip W Iversen

Clin Cancer Res· March 2013

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Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.
Bo Tan, Debra A Young, Zhao-Hai Lu, Tao Wang, Timothy I Meier, Robert L Shepard

J Biol Chem· February 2013

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Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
William L Perry, Robert L Shepard, Janardhan Sampath, Benjamin Yaden, William W Chin

Cancer Res· August 2005

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The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Susan Pratt, Robert L Shepard, Ramani A Kandasamy, Paul A Johnston, William Perry

Mol Cancer Ther· May 2005

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Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Anne H Dantzig, Robert L Shepard, Susan E Pratt, Linda B Tabas, Peter A Lander

Biochem Pharmacol· March 2004

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Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.
Janardhan Sampath, Pandy R Long, Robert L Shepard, Xiaoling Xia, Viswanath Devanarayan

Am J Pathol· November 2003

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Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.
Robert L Shepard, Jin Cao, James J Starling, Anne H Dantzig

Int J Cancer· January 2003

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Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.
Yue-Ming Qian, Caroline E Grant, Christopher J Westlake, Da-Wei Zhang, Peter A Lander, Robert L Shepard

J Biol Chem· September 2002

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GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.
Qingcheng Mao, Wei Qiu, Kevin E Weigl, Peter A Lander, Linda B Tabas, Robert L Shepard

J Biol Chem· August 2002

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Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Sean Ekins, Richard B Kim, Brenda F Leake, Anne H Dantzig, Erin G Schuetz, Robert L Shepard

Mol Pharmacol· May 2002

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Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Sean Ekins, Richard B Kim, Brenda F Leake, Anne H Dantzig, Erin G Schuetz, Robert L Shepard

Mol Pharmacol· May 2002

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