Publications by authors named "Anne Hassell"

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Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
Samarjit Patnaik, Kirk L Stevens, Roseanne Gerding, Felix Deanda, J Brad Shotwell, Anne M Hassell

Bioorg Med Chem Lett· June 2009

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Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Kyle A Emmitte, Brian J Wilson, Erich W Baum, Holly K Emerson, Kevin W Kuntz, Anne M Hassell

Bioorg Med Chem Lett· February 2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
Stanley D Chamberlain, Joseph W Wilson, Felix Deanda, Samarjit Patnaik, Anikó M Redman, Anne M Hassell

Bioorg Med Chem Lett· January 2009

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Stanley D Chamberlain, Anikó M Redman, Joseph W Wilson, Felix Deanda, J Brad Shotwell, Anne M Hassell

Bioorg Med Chem Lett· January 2009

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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Kirk L Stevens, Michael J Reno, Jennifer B Alberti, Daniel J Price, Laurie S Kane-Carson, Anne M Hassell

Bioorg Med Chem Lett· November 2008

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X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.
Keith Biggadike, Randy K Bledsoe, Anne M Hassell, Barrie E Kirk, Iain M McLay

J Med Chem· June 2008

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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Edgar R Wood, Lisa M Shewchuk, Byron Ellis, Perry Brignola, Ronald L Brashear, Anne M Hassell

Proc Natl Acad Sci U S A· February 2008

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Crystallization of protein-ligand complexes.
Anne M Hassell, Gang An, Randy K Bledsoe, Jane M Bynum, H Luke Carter

Acta Crystallogr D Biol Crystallogr· January 2007

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Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.
David G Barrett, John G Catalano, David N Deaton, Anne M Hassell, Stacey T Long

Bioorg Med Chem Lett· March 2006

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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Kim K Adkison, David G Barrett, David N Deaton, Robert T Gampe, Anne M Hassell

Bioorg Med Chem Lett· February 2006

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P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.
David G Barrett, Virginia M Boncek, John G Catalano, David N Deaton, Anne M Hassell

Bioorg Med Chem Lett· August 2005

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Acyclic cyanamide-based inhibitors of cathepsin K.
David G Barrett, David N Deaton, Anne M Hassell, Robert B McFadyen, Aaron B Miller

Bioorg Med Chem Lett· June 2005

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Novel and potent cyclic cyanamide-based cathepsin K inhibitors.
David N Deaton, Anne M Hassell, Robert B McFadyen, Aaron B Miller, Larry R Miller

Bioorg Med Chem Lett· April 2005

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Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions.
David G Barrett, John G Catalano, David N Deaton, Anne M Hassell, Stacey T Long

Bioorg Med Chem Lett· October 2004

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Edgar R Wood, Anne T Truesdale, Octerloney B McDonald, Derek Yuan, Anne Hassell

Cancer Res· September 2004

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Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors.
Eric E Boros, David N Deaton, Anne M Hassell, Robert B McFadyen, Aaron B Miller

Bioorg Med Chem Lett· July 2004

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Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k.
Francis X Tavares, Virginia Boncek, David N Deaton, Anne M Hassell, Stacey T Long

J Med Chem· January 2004

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Lipopolysaccharide down-regulates inducible nitric oxide synthase expression in swine heart in vivo.
Rubin I Cohen, Anne Marie Hassell, Xiaobing Ye, Kamel Marzouk, Shu Fang Liu

Biochem Biophys Res Commun· August 2003

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Retraction.
Stephen T Davis, Bill G Benson, H Neal Bramson, Dennis E Chapman, Scott H Dickerson, Anne M Hassell

Science· December 2002

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