Publications by authors named "Annette Burkhart"

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A novel vector design targeting the blood-brain barrier with the brain-specific AAV-BR1 vector enables abluminal protein secretion from brain endothelial cells in vitro.
Bartosz Laczek, Maj Schneider Thomsen, Jakob Körbelin, Annette Burkhart, Torben Moos

Fluids Barriers CNS· December 2025

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Dietary Iron Deficiency in Adult Mice Increases Brain Uptake of High-Affinity, Anti-Transferrin Receptor Antibody RI7217.
Serhii Kostrikov, Kasper Bendix Johnsen, Annette Burkhart, Steinunn Sara Helgudóttir, Thomas Lars Andresen

J Neurochem· November 2025

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Correction: Reporting preclinical gene therapy studies in the field of Niemann-Pick type C disease according to the ARRIVE guidelines.
Charlotte Laurfelt Munch Rasmussen, Annette Burkhart, Torben Moos, Louiza Bohn Thomsen

Orphanet J Rare Dis· June 2025

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Reporting preclinical gene therapy studies in the field of Niemann-Pick type C disease according to the ARRIVE guidelines.
Charlotte Laurfelt Munch Rasmussen, Annette Burkhart, Torben Moos, Louiza Bohn Thomsen

Orphanet J Rare Dis· May 2025

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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2.
Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Annette Burkhart

Fluids Barriers CNS· January 2025

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Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro.
Annette Burkhart, Steinunn Sara Helgudóttir, Yahye A Mahamed, Mikkel B Fruergaard, Julie N Holm-Jacobsen

Sci Rep· November 2024

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Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia.
Annette Burkhart, Kasper Bendix Johnsen, Tina Skjørringe, Asbjørn Haaning Nielsen, Lisa Juul Routhe

Nutrients· September 2024

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Targeted transport of biotherapeutics at the blood-brain barrier.
Torben Moos, Maj Schneider Thomsen, Annette Burkhart, Eva Hede, Bartosz Laczek

Expert Opin Drug Deliv· January 2024

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The Npc2 mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease.
Charlotte Laurfelt Munch Rasmussen, Louiza Bohn Thomsen, Christian Würtz Heegaard, Torben Moos, Annette Burkhart

Mol Cell Neurosci· September 2023

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Circulating ECVs prevent neurodegeneration and preserve neuronal function in a model of preclinical intracerebral hemorrhage.
Annette Burkhart, Torben Moos

Mol Ther Nucleic Acids· June 2023

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A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus.
Charlotte Laurfelt Munch Rasmussen, Eva Hede, Lisa Juul Routhe, Jakob Körbelin, Steinunn Sara Helgudottir, Annette Burkhart

J Neurochem· January 2023

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Sortilin regulates blood-brain barrier integrity.
Andrea E Toth, Hans C Helms, Andras Harazin, Kasper B Johnsen, Charlotte Goldeman, Annette Burkhart

FEBS J· February 2022

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The blood-brain barrier studied in vitro across species.
Maj Schneider Thomsen, Nanna Humle, Eva Hede, Torben Moos, Annette Burkhart

PLoS One· August 2021

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Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease.
Eva Hede, Christine B Christiansen, Christian W Heegaard, Torben Moos, Annette Burkhart

J Neurochem· February 2021

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Epigenetic Regulation of Ferroportin in Primary Cultures of the Rat Blood-Brain Barrier.
Steinunn Sara Helgudottir, Lisa J Routhe, Annette Burkhart, Katrine Jønsson, Inge S Pedersen

Mol Neurobiol· August 2020

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Targeting the transferrin receptor for brain drug delivery.
Kasper Bendix Johnsen, Annette Burkhart, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos

Prog Neurobiol· October 2019

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Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.
Kasper Bendix Johnsen, Martin Bak, Paul Joseph Kempen, Fredrik Melander, Annette Burkhart

Theranostics· August 2019

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Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-Like PC12 Cells Subjected to Iron Challenge.
Steinunn Sara Helgudottir, Jacek Lichota, Annette Burkhart, Torben Moos

Mol Neurobiol· April 2019

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Correction to: Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-like PC12 Cells Subjected to Iron Challenge.
Steinunn Sara Helgudottir, Jacek Lichota, Annette Burkhart, Torben Moos

Mol Neurobiol· April 2019

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Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo.
Kasper Bendix Johnsen, Martin Bak, Fredrik Melander, Maj Schneider Thomsen, Annette Burkhart

J Control Release· February 2019

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Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.
Kasper Bendix Johnsen, Annette Burkhart, Fredrik Melander, Paul Joseph Kempen, Jonas Bruun Vejlebo

Sci Rep· September 2017

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Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain.
Annette Burkhart, Thomas Lars Andresen, Achim Aigner, Louiza Bohn Thomsen, Torben Moos

Cell Mol Life Sci· July 2017

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Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier.
Maj Schneider Thomsen, Svend Birkelund, Annette Burkhart, Allan Stensballe, Torben Moos

J Neurochem· March 2017

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Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier.
Annette Burkhart, Tina Skjørringe, Kasper Bendix Johnsen, Piotr Siupka, Louiza Bohn Thomsen

Mol Neurobiol· December 2016

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Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties.
Annette Burkhart, Louiza Bohn Thomsen, Maj Schneider Thomsen, Jacek Lichota, Csilla Fazakas

Fluids Barriers CNS· August 2015

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