Publications by authors named "Anthony Fehr"

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SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response.
Nicholas A Parenti, Renee Cusic, David M Renner, Nathaniel Jackson, Chengjin Ye, Anthony R Fehr

bioRxiv· December 2025

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An Autoimmunity-associated allele of enhances innate antiviral immunity to protect against acute coronavirus infection.
Alec M Bevis, Kathryn J L H Rosa, Nancy Schwarting, Tammy R Cockerham, Catherine M Kerr, Anthony R Fehr

bioRxiv· October 2025

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PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses.
Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J Pfannenstiel, Anthony R Fehr

mBio· October 2025

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Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle.
Joseph J O'Connor, Anuradha Roy, Reem Khattabi, Catherine Kerr, Nancy Schwarting, Anthony R Fehr

J Virol· August 2025

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Quorum sensing regulation by the nitrogen phosphotransferase system in .
Samalee Banerjee, Nicole E Smalley, Pradtahna Saenjamsai, Anthony R Fehr, Ajai A Dandekar

J Bacteriol· August 2025

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Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.
Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M Sherrill, Iain Colquhoun, Anthony R Fehr

mBio· June 2025

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IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.
Catherine M Kerr, Macie A Proctor-Roser, Srivatsan Parthasarathy, Joseph J O'Connor, Jessica J Pfannenstiel, Anthony R Fehr

PLoS One· June 2025

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PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses.
Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J Pfannenstiel, Anthony R Fehr

bioRxiv· April 2025

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Quorum sensing regulation by the nitrogen phosphotransferase system in .
Samalee Banerjee, Nicole E Smalley, Pradtahna Saenjamsai, Anthony Fehr, Ajai A Dandekar

bioRxiv· February 2025

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IFN- signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.
Catherine M Kerr, Macie A Proctor-Roser, Srivatsan Parthasarathy, Joseph J O'Connor, Jessica J Pfannenstiel, Anthony R Fehr

bioRxiv· January 2025

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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Catherine M Kerr, Jessica J Pfannenstiel, Yousef M Alhammad, Joseph J O'Connor, Roshan Ghimire, Anthony R Fehr

J Virol· November 2024

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Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.
Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavania M Sherrill, Iain Colquhoun, Anthony R Fehr

bioRxiv· October 2024

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Mutation of a highly conserved isoleucine residue in loop 2 of several -coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Catherine M Kerr, Jessica J Pfannenstiel, Yousef M Alhammad, Joseph J O'Connor, Roshan Ghimire, Anthony R Fehr

bioRxiv· July 2024

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SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.
Clayton J Otter, Nicole Bracci, Nicholas A Parenti, Chengjin Ye, Abhishek Asthana, Anthony R Fehr

Proc Natl Acad Sci U S A· April 2024

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Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
Sarah Wazir, Tomi A O Parviainen, Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Anthony R Fehr

J Med Chem· April 2024

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Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
Sarah Wazir, Tomi A O Parviainen, Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Anthony R Fehr

bioRxiv· December 2023

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SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.
Clayton J Otter, Nicole Bracci, Nicholas A Parenti, Chengjin Ye, Li Hui Tan, Anthony R Fehr

bioRxiv· November 2023

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An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors.
Joseph J O'Connor, Dana Ferraris, Anthony R Fehr

Pathogens· October 2023

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PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
Catherine M Kerr, Srivatsan Parthasarathy, Nancy Schwarting, Joseph J O'Connor, Jessica J Pfannenstiel, Anthony R Fehr

J Virol· September 2023

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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Yousef M Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Catherine M Kerr, Joseph J O'Connor, Anthony R Fehr

Proc Natl Acad Sci U S A· August 2023

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Two Commercially Available Blood-Stabilization Reagents Serve as Potent Inactivators of Coronaviruses.
Joseph J O'Connor, Lynden Voth, Jeremiah Athmer, Nicholas M George, Christopher M Connelly, Anthony R Fehr

Pathogens· August 2023

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PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner.
Catherine M Kerr, Srivatsan Parthasarathy, Nancy Schwarting, Joseph J O'Connor, Emily Giri, Anthony R Fehr

bioRxiv· June 2023

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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Yousef M Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Joseph J O'Connor, Catherine M Kerr, Anthony R Fehr

bioRxiv· April 2023

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Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles.
Cindy Y Ly, Jessica Pfannenstiel, Anil Pant, Zhilong Yang, Anthony R Fehr

Microbiol Spectr· February 2023

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PARP14: A key ADP-ribosylating protein in host-virus interactions?
Srivatsan Parthasarathy, Anthony R Fehr

PLoS Pathog· June 2022

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