Publications by authors named "Anusha Sebastian"

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Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Anusha Sebastian, Reinad R Abu Rabah, Seyed-Omar Zaraei, Srinivasulu Vunnam, Shaista Sultan

Eur J Med Chem· August 2024

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Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19.
Fatema Hersi, Anusha Sebastian, Hamadeh Tarazi, Vunnam Srinivasulu, Ahmed Mostafa

Eur J Med Chem· June 2023

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Divergent Protocol for the Synthesis of Isoquinolino[1,2-]quinazolinone and Isoquinolino[2,1-]quinazolinone Derivatives.
Bilal O Alkubaisi, Anil Ravi, Gourishetty Srikanth, Anusha Sebastian, Monther A Khanfar

J Org Chem· April 2023

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Stereodivergent Desymmetrization of Phenols En Route to Modular Access to Densely Functionalized Quinazoline and Oxazine Scaffolds.
Gourishetty Srikanth, Anil Ravi, Anusha Sebastian, Monther A Khanfar, Imad A Abu-Yousef

J Org Chem· February 2023

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Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Reinad R Abu Rabah, Anusha Sebastian, Srinivasulu Vunnam, Shaista Sultan, Hamadeh Tarazi

Bioorg Med Chem· September 2022

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Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.
Vunnam Srinivasulu, Gourishetty Srikanth, Monther A Khanfar, Imad A Abu-Yousef, Amin F Majdalawieh, Anusha Sebastian

J Org Chem· January 2022

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Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise.
Noura Khaiwa, Noor R Maarouf, Mhd H Darwish, Dima W M Alhamad, Anusha Sebastian

Eur J Med Chem· November 2021

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Stereoselective Late-Stage Transformations of Indolo[2,3-]quinolizines Skeleta to Nature-Inspired Scaffolds.
Vunnam Srinivasulu, Scott McN Sieburth, Monther A Khanfar, Imad A Abu-Yousef, Amin Majdalawieh, Anusha Sebastian

J Org Chem· September 2021

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Stereocontrolled transformations of cyclohexadienone derivatives to access stereochemically rich and natural product-inspired architectures.
Taleb H Al-Tel, Vunnam Srinivasulu, Mani Ramanathan, Nelson C Soares, Anusha Sebastian

Org Biomol Chem· November 2020

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Domino Transformations of Ene/Yne Tethered Salicylaldehyde Derivatives: Pluripotent Platforms for the Construction of High sp Content and Privileged Architectures.
Anusha Sebastian, Vunnam Srinivasulu, Imad A Abu-Yousef, Orive Gorka, Taleb H Al-Tel

Chemistry· December 2019

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Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs.
Vunnam Srinivasulu, Monther Khanfar, Hany A Omar, Raafat ElAwady, Scott McN Sieburth, Anusha Sebastian

J Org Chem· November 2019

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One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems.
Vunnam Srinivasulu, Ihsan Shehadeh, Monther A Khanfar, Omar G Malik, Hamadeh Tarazi, Anusha Sebastian

J Org Chem· January 2019

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Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds.
Vunnam Srinivasulu, Paul Schilf, Saleh Ibrahim, Monther A Khanfar, Scott McN Sieburth, Anusha Sebastian

Nat Commun· November 2018

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Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer.
Anusha Sebastian, Vijay Pandey, Chakrabhavi Dhananjaya Mohan, Yi Ting Chia, Shobith Rangappa

ACS Omega· December 2016

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Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum.
Gowtham Subramanian, C P Babu Rajeev, Chakrabhavi Dhananjaya Mohan, Ameya Sinha, Trang T T Chu, Sebastian Anusha

Bioorg Med Chem Lett· July 2016

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A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51).
Sebastian Anusha, Baburajeev Cp, Chakrabhavi Dhananjaya Mohan, Jessin Mathai, Shobith Rangappa

PLoS One· June 2016

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Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs.
Sebastian Anusha, Chakrabhavi Dhananjaya Mohan, Hanumappa Ananda, C P Baburajeev, Shobith Rangappa

Bioorg Med Chem Lett· February 2016

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Synthesis, characterization and in vitro evaluation of novel enantiomerically-pure sulphonamide antimalarials.
Sebastian Anusha, Ameya Sinha, C P Babu Rajeev, Trang T T Chu, Jessin Mathai

Org Biomol Chem· November 2015

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Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation.
Nanjundaswamy Ashwini, Manoj Garg, Chakrabhavi Dhananjaya Mohan, Julian E Fuchs, Shobith Rangappa, Sebastian Anusha

Bioorg Med Chem· September 2015

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Novel apigenin based small molecule that targets snake venom metalloproteases.
Venkatachalaiah Srinivasa, Mahalingam S Sundaram, Sebastian Anusha, Mahadevappa Hemshekhar, Siddaiah Chandra Nayaka

PLoS One· May 2015

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