Publications by authors named "Ari Hashimoto"

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Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives.
Ari Hashimoto, Shigeru Hashimoto

Cancers (Basel)· December 2024

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p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus.
Tsukasa Oikawa, Junya Hasegawa, Haruka Handa, Naomi Ohnishi, Yasuhito Onodera, Ari Hashimoto

Life Sci Alliance· September 2024

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DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.
Seiichiro Naito, Hiroki Tanaka, Jing-Jing Jiang, Masato Tarumi, Ari Hashimoto, Shigeru Hashimoto

Biochem Biophys Res Commun· April 2024

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ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity.
Ari Hashimoto, Shigeru Hashimoto

Int J Mol Sci· October 2023

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Computer model of IL-6-dependent rheumatoid arthritis in F759 mice.
Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Shigeru Hashimoto

Int Immunol· September 2023

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Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer.
Nabeel Kajihara, Takuto Kobayashi, Ryo Otsuka, Junko Nio-Kobayashi, Tomohiro Oshino, Ari Hashimoto

Cancer Immunol Immunother· April 2023

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A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling.
Taiga Maemoto, Yuichi Kitai, Runa Takahashi, Haruka Shoji, Shunsuke Yamada, Ari Hashimoto, Shigeru Hashimoto

J Biol Chem· January 2023

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Orchestration of mesenchymal plasticity and immune evasiveness rewiring of the metabolic program in pancreatic ductal adenocarcinoma.
Ari Hashimoto, Haruka Handa, Soichiro Hata, Shigeru Hashimoto

Front Oncol· November 2022

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Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance.
Shigeru Hashimoto, Ari Hashimoto, Ryuta Muromoto, Yuichi Kitai, Kenji Oritani

Cells· August 2022

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Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.
Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Shigeru Hashimoto

Cancer Immunol Res· August 2021

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Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Shigeru Hashimoto

Cell Commun Signal· May 2021

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High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi

Cell Commun Signal· June 2020

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ARF6 and AMAP1 are major targets of and mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.
Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao

Proc Natl Acad Sci U S A· August 2019

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Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.
Yuichi Mazaki, Tsunehito Higashi, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Shigeru Hashimoto

FEBS Lett· March 2019

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Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa

Cell Commun Signal· December 2018

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Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells.
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hisataka Sabe

Small GTPases· September 2018

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Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model.
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Ari Hashimoto

Cell Commun Signal· January 2018

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Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma.
Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto

Urol Oncol· September 2017

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High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue.
Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto

Cell Commun Signal· November 2016

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Tumor responsiveness to statins requires overexpression of the ARF6 pathway.
Hisataka Sabe, Ari Hashimoto, Shigeru Hashimoto, Tsukasa Oikawa

Mol Cell Oncol· July 2016

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P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa

J Cell Biol· April 2016

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Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto

Nat Commun· February 2016

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Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.
Rumiko Kinoshita, Jin-Min Nam, Yoichi M Ito, Kanako C Hatanaka, Ari Hashimoto, Shigeru Hashimoto

PLoS One· August 2014

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AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.
Dat Nguyen Tien, Masako Kishihata, Ayumu Yoshikawa, Ari Hashimoto, Hisataka Sabe

Sci Rep· May 2014

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High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients.
Hiroki Sato, Kanako C Hatanaka, Yutaka Hatanaka, Hiromitsu Hatakeyama, Ari Hashimoto

Cell Commun Signal· March 2014

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