Publications by authors named "Shigeru Hashimoto"

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EVA1-antibody drug conjugate is a new therapeutic strategy for eliminating glioblastoma-initiating cells.
Jiahui Hou, Tamami Uejima, Miho Tanaka, You Lee Son, Kazuharu Hanada, Shigeru Hashimoto

Neuro Oncol· March 2025

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Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives.
Ari Hashimoto, Shigeru Hashimoto

Cancers (Basel)· December 2024

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GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis.
Ryutaro Furukawa, Masaki Kuwatani, Jing-Jing Jiang, Yuki Tanaka, Rie Hasebe, Shigeru Hashimoto

Sci Rep· May 2024

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DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.
Seiichiro Naito, Hiroki Tanaka, Jing-Jing Jiang, Masato Tarumi, Ari Hashimoto, Shigeru Hashimoto

Biochem Biophys Res Commun· April 2024

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High-precision rapid testing of omicron SARS-CoV-2 variants in clinical samples using AI-nanopore.
Kaoru Murakami, Shimpei I Kubota, Kumiko Tanaka, Hiroki Tanaka, Keiichiroh Akabane, Shigeru Hashimoto

Lab Chip· November 2023

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ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity.
Ari Hashimoto, Shigeru Hashimoto

Int J Mol Sci· October 2023

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Computer model of IL-6-dependent rheumatoid arthritis in F759 mice.
Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Shigeru Hashimoto

Int Immunol· September 2023

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Dupuytren's contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development.
Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Shigeru Hashimoto

Int Immunol· July 2023

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Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients.
Takeshi Yamasaki, Noriyuki Nagata, Toru Atsumi, Rie Hasebe, Yuki Tanaka, Shigeru Hashimoto

Int Immunol· July 2023

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GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation.
Shiina Matsuyama, Reiji Yamamoto, Kaoru Murakami, Nobuhiko Takahashi, Rieko Nishi, Shigeru Hashimoto

J Immunol· July 2023

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A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling.
Taiga Maemoto, Yuichi Kitai, Runa Takahashi, Haruka Shoji, Shunsuke Yamada, Ari Hashimoto, Shigeru Hashimoto

J Biol Chem· January 2023

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Roles of RNA-binding proteins in immune diseases and cancer.
Shigeru Hashimoto, Tadamitsu Kishimoto

Semin Cancer Biol· November 2022

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Orchestration of mesenchymal plasticity and immune evasiveness rewiring of the metabolic program in pancreatic ductal adenocarcinoma.
Ari Hashimoto, Haruka Handa, Soichiro Hata, Shigeru Hashimoto

Front Oncol· November 2022

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Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance.
Shigeru Hashimoto, Ari Hashimoto, Ryuta Muromoto, Yuichi Kitai, Kenji Oritani

Cells· August 2022

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The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally

Cancer Lett· November 2021

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Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.
Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Shigeru Hashimoto

Cancer Immunol Res· August 2021

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Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Shigeru Hashimoto

Cell Commun Signal· May 2021

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High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi

Cell Commun Signal· June 2020

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Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.
Hozaifa Metwally, Toshio Tanaka, Songling Li, Gyanu Parajuli, Sujin Kang, Shigeru Hashimoto

Sci Signal· March 2020

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ARF6 and AMAP1 are major targets of and mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.
Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao

Proc Natl Acad Sci U S A· August 2019

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Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis.
Jaya Prakash Chalise, Shigeru Hashimoto, Gyanu Parajuli, Sujin Kang, Shailendra Kumar Singh

Proc Natl Acad Sci U S A· July 2019

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Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.
Yuichi Mazaki, Tsunehito Higashi, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Shigeru Hashimoto

FEBS Lett· March 2019

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Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa

Cell Commun Signal· December 2018

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Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs.
Yohannes Gemechu, David Millrine, Shigeru Hashimoto, Jaya Prakash, Ksenia Sanchenkova

Proc Natl Acad Sci U S A· November 2018

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Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity.
Tsukasa Oikawa, Yutaro Otsuka, Yasuhito Onodera, Mei Horikawa, Haruka Handa, Shigeru Hashimoto

Sci Rep· January 2018

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