Publications by authors named "Arthur A Simen"

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M1 receptor positive allosteric modulators discovery approaches.
Takao Mandai, Arthur A Simen, Antonio Laurenza, Haruhide Kimura

Trends Pharmacol Sci· April 2025

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An Acetylcholine M1 Receptor-Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment: A Phase 2 Randomized Clinical Trial.
Niraj M Shanbhag, Jaya L Padmanabhan, Zheng Zhang, Brian T Harel, Hongxia Jia, Arthur A Simen

JAMA Neurol· February 2025

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Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Danielle Beckman, Giovanne B Diniz, Sean Ott, Brad Hobson, Abhijit J Chaudhari, Arthur A Simen

Alzheimers Dement· August 2024

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Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
Wei Yin, Fahimeh Mamashli, Derek L Buhl, Polyna Khudyakov, Dmitri Volfson, Arthur A Simen

Br J Clin Pharmacol· February 2022

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Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder.
Steven D Targum, Christopher Murphy, Jibran Khan, Laura Zumpano, Mark Whitlock, Arthur A Simen

Innov Clin Neurosci· April 2018

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The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.
Janitza L Montalvo-Ortiz, Kelly A Bordner, Becky C Carlyle, Joel Gelernter, Arthur A Simen

Behav Brain Res· December 2016

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A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone.
Arthur A Simen, Cynthia Gargano, Jang-Ho Cha, Melissa Drexel, An Bautmans

Ther Adv Drug Saf· June 2015

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Efavirenz modulation of sleep spindles and sleep spectral profile.
Arthur A Simen, Junshui Ma, Vladimir Svetnik, David Mayleben, James Maynard

J Sleep Res· February 2015

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Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.
Lynda El-Hassar, Arthur A Simen, Alvaro Duque, Kiran D Patel, Leonard K Kaczmarek

Biol Psychiatry· September 2014

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cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex.
Becky C Carlyle, Angus C Nairn, Min Wang, Yang Yang, Lu E Jin, Arthur A Simen

Proc Natl Acad Sci U S A· April 2014

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Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects.
Vanja Duric, Mounira Banasr, Craig A Stockmeier, Arthur A Simen, Samuel S Newton

Int J Neuropsychopharmacol· February 2013

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Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits.
Becky C Carlyle, Alvaro Duque, Robert R Kitchen, Kelly A Bordner, Daniel Coman, Arthur A Simen

Dev Psychopathol· November 2012

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Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.
Andrew M McIntosh, Arthur A Simen, Kathryn L Evans, Jeremy Hall, Donald J Macintyre

Front Genet· October 2012

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Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.
Huiping Zhang, Aryeh I Herman, Henry R Kranzler, Raymond F Anton, Arthur A Simen

J Hum Genet· October 2012

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Neuroanatomical changes in a mouse model of early life neglect.
Alvaro Duque, Daniel Coman, Becky C Carlyle, Kelly A Bordner, Elizabeth D George, Arthur A Simen

Brain Struct Funct· April 2012

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Under-treatment of depression in older persons.
Lisa C Barry, Janet J Abou, Arthur A Simen, Thomas M Gill

J Affect Disord· February 2012

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Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments.
Robert R Kitchen, Vicky S Sabine, Arthur A Simen, J Michael Dixon, John M S Bartlett

BMC Genomics· December 2011

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Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortex.
Kelly A Bordner, Robert R Kitchen, Becky Carlyle, Elizabeth D George, Milind C Mahajan, Arthur A Simen

Exp Gerontol· August 2011

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Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect.
Kelly A Bordner, Elizabeth D George, Becky C Carlyle, Alvaro Duque, Robert R Kitchen, Arthur A Simen

Front Psychiatry· July 2011

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Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder.
Benjamin Kelmendi, Márcia Holsbach-Beltrame, Andrew M McIntosh, Lori Hilt, Elizabeth D George, Arthur A Simen

Neurosci Lett· June 2011

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Cognitive dysfunction with aging and the role of inflammation.
Arthur A Simen, Kelly A Bordner, Mark P Martin, Lawrence A Moy, Lisa C Barry

Ther Adv Chronic Dis· May 2011

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A negative regulator of MAP kinase causes depressive behavior.
Vanja Duric, Mounira Banasr, Pawel Licznerski, Heath D Schmidt, Craig A Stockmeier, Arthur A Simen

Nat Med· November 2010

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Maternal separation with early weaning: a novel mouse model of early life neglect.
Elizabeth D George, Kelly A Bordner, Hani M Elwafi, Arthur A Simen

BMC Neurosci· September 2010

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Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.
Huiping Zhang, Joel Gelernter, Jeffrey R Gruen, Henry R Kranzler, Aryeh I Herman, Arthur A Simen

J Hum Genet· May 2010

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Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians.
Joshua T Kantrowitz, Karen A Nolan, Srijan Sen, Arthur A Simen, Herbert M Lachman

Psychiatr Q· December 2009

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