Publications by authors named "Mark Whitlock"

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Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19.
Philip Robinson, Sima S Toussi, Sudeepta Aggarwal, Arthur Bergman, Tong Zhu, Mark Whitlock

Open Forum Infect Dis· August 2023

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A phase 2a, randomized, double-blind, placebo-controlled, three-arm, parallel-group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF-06835919 in patients with non-alcoholic fatty liver disease and type 2 diabetes.
Aditi R Saxena, Stephanie-An Lyle, Kaivan Khavandi, Ruolun Qiu, Mark Whitlock

Diabetes Obes Metab· April 2023

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Mixed meal tolerance testing highlights in diabetes altered branched-chain ketoacid metabolism and pathways associated with all-cause mortality.
Michael Y Mi, Mark Whitlock, Xu Shi, Laurie A Farrell, Victoria M Bhambhani

Am J Clin Nutr· March 2023

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Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5-Subtype Selective GABA -Positive Allosteric Modulator PF-06372865 in Healthy Volunteers.
Rachel Gurrell, Mark Whitlock, Hua Wei, Zhongzhou Shen, Adam Ogden

Clin Pharmacol Drug Dev· July 2021

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Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA partial agonist, in humans.
Guido van Amerongen, Pieter S Siebenga, Rachel Gurrell, Pinky Dua, Mark Whitlock

Br J Anaesth· August 2019

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Response to "Treating patients rather than their functional neuroimages" (Br J Anaesth 2018; 121: 969-71).
Vishvarani Wanigasekera, Karolina Wartolowska, John P Huggins, Eugene P Duff, William Vennart, Mark Whitlock

Br J Anaesth· August 2019

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Is High Placebo Response Really a Problem in Depression Trials? A Critical Re-analysis of Depression Studies.
Mark E Whitlock, Philip W Woodward, Robert C Alexander

Innov Clin Neurosci· July 2019

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Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
Rachel Gurrell, Donal Gorman, Mark Whitlock, Adam Ogden, David S Reynolds

Neurology· April 2019

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An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder.
Arthur Simen, Mark Whitlock, Ruolun Qiu, Jeff Miceli, Laura Zumpano

J Clin Psychopharmacol· March 2019

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A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain.
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock

Pain· September 2018

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Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.
Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Mark Whitlock

Nat Biotechnol· April 2018

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Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder.
Steven D Targum, Christopher Murphy, Jibran Khan, Laura Zumpano, Mark Whitlock

Innov Clin Neurosci· April 2018

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Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA receptor positive allosteric modulator PF-06372865.
Sarah A Nickolls, Rachel Gurrell, Guido van Amerongen, Juha Kammonen, Lishuang Cao, Mark Whitlock

Br J Pharmacol· February 2018

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Learning to identify CNS drug action and efficacy using multistudy fMRI data.
Eugene P Duff, William Vennart, Richard G Wise, Matthew A Howard, Richard E Harris, Mark Whitlock

Sci Transl Med· February 2015

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Characterization, optimisation and process robustness of a co-processed mannitol for the development of orally disintegrating tablets.
Josephine Lay Peng Soh, Maud Grachet, Mark Whitlock, Timothy Lukas

Pharm Dev Technol· February 2013

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The scientific basis for the duration of stability data required at the time of submission.
Jon Beaman, Mark Whitlock, Ross Wallace, Allan Edwards

J Pharm Sci· June 2010

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Raman mapping of low-content active-ingredient pharmaceutical formulations. part II: statistically optimized sampling for detection of less than 1% of an active pharmaceutical ingredient.
Slobodan Sasić, Mark Whitlock

Appl Spectrosc· August 2008

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Induced hepatic fibrosis in rats: hepatic steatosis, macromolecule content, perfusion parameters, and their correlations--preliminary MR imaging in rats.
Hyeonjin Kim, Carmen J Booth, Alexander B Pinus, Pengyu Chen, Andrew Lee, Mark Whitlock

Radiology· June 2008

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