Publications by authors named "Arthur Simen"

Claim this Profile
P
Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment.
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan, Arthur Simen

Clin Pharmacol Drug Dev· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phase 1, randomized trials of MEDI1341: cerebrospinal fluid free α-synuclein lowered by >50.
Craig Shering, Michael Pomfret, Robert J Kubiak, Isabelle J Pouliquen, Wei Yin, Arthur Simen

Brain Commun· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
M1 receptor positive allosteric modulators discovery approaches.
Takao Mandai, Arthur A Simen, Antonio Laurenza, Haruhide Kimura

Trends Pharmacol Sci· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An Acetylcholine M1 Receptor-Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment: A Phase 2 Randomized Clinical Trial.
Niraj M Shanbhag, Jaya L Padmanabhan, Zheng Zhang, Brian T Harel, Hongxia Jia, Arthur A Simen

JAMA Neurol· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Danielle Beckman, Giovanne B Diniz, Sean Ott, Brad Hobson, Abhijit J Chaudhari, Arthur A Simen

Alzheimers Dement· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identifying individuals with non-Alzheimer's disease co-pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease.
Duygu Tosun, Ozlem Yardibi, Tammie L S Benzinger, Walter A Kukull, Colin L Masters, Arthur Simen

Alzheimers Dement· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Investigation of genetic determinants of cognitive change in later life.
Liam Mahedy, Emma L Anderson, Kate Tilling, Zak A Thornton, Andrew R Elmore, Arthur Simen

Transl Psychiatry· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
Wei Yin, Fahimeh Mamashli, Derek L Buhl, Polyna Khudyakov, Dmitri Volfson, Arthur A Simen

Br J Clin Pharmacol· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder.
Arthur Simen, Mark Whitlock, Ruolun Qiu, Jeff Miceli, Laura Zumpano

J Clin Psychopharmacol· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder.
Steven D Targum, Christopher Murphy, Jibran Khan, Laura Zumpano, Mark Whitlock, Arthur A Simen

Innov Clin Neurosci· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.
Janitza L Montalvo-Ortiz, Kelly A Bordner, Becky C Carlyle, Joel Gelernter, Arthur A Simen

Behav Brain Res· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone.
Arthur A Simen, Cynthia Gargano, Jang-Ho Cha, Melissa Drexel, An Bautmans

Ther Adv Drug Saf· June 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efavirenz modulation of sleep spindles and sleep spectral profile.
Arthur A Simen, Junshui Ma, Vladimir Svetnik, David Mayleben, James Maynard

J Sleep Res· February 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.
Lynda El-Hassar, Arthur A Simen, Alvaro Duque, Kiran D Patel, Leonard K Kaczmarek

Biol Psychiatry· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.
Natalie Weder, Huiping Zhang, Kevin Jensen, Bao Zhu Yang, Arthur Simen

J Am Acad Child Adolesc Psychiatry· April 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex.
Becky C Carlyle, Angus C Nairn, Min Wang, Yang Yang, Lu E Jin, Arthur A Simen

Proc Natl Acad Sci U S A· April 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence.
Fan Wang, Arthur Simen, Albert Arias, Qun-Wei Lu, Huiping Zhang

Hum Genet· March 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects.
Vanja Duric, Mounira Banasr, Craig A Stockmeier, Arthur A Simen, Samuel S Newton

Int J Neuropsychopharmacol· February 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients.
Gonzalo Laje, Níall Lally, Daniel Mathews, Nancy Brutsche, Anat Chemerinski, Arthur Simen

Biol Psychiatry· December 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits.
Becky C Carlyle, Alvaro Duque, Robert R Kitchen, Kelly A Bordner, Daniel Coman, Arthur A Simen

Dev Psychopathol· November 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.
Andrew M McIntosh, Arthur A Simen, Kathryn L Evans, Jeremy Hall, Donald J Macintyre

Front Genet· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.
Huiping Zhang, Aryeh I Herman, Henry R Kranzler, Raymond F Anton, Arthur A Simen

J Hum Genet· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Under-treatment of depression in older persons.
Lisa C Barry, Janet J Abou, Arthur A Simen, Thomas M Gill

J Affect Disord· February 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.
Lan Wei, Arthur Simen, Shrikant Mane, Arie Kaffman

Neuropsychopharmacology· January 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments.
Robert R Kitchen, Vicky S Sabine, Arthur A Simen, J Michael Dixon, John M S Bartlett

BMC Genomics· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis