Publications by authors named "David S Reynolds"

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Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.
Caroline L Benn, Karl R Gibson, David S Reynolds

J Huntingtons Dis· November 2021

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A short perspective on the long road to effective treatments for Alzheimer's disease.
David S Reynolds

Br J Pharmacol· September 2019

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Design and Identification of a Novel, Functionally Subtype Selective GABA Positive Allosteric Modulator (PF-06372865).
Robert M Owen, David Blakemore, Lishuang Cao, Neil Flanagan, Rebecca Fish, David S Reynolds

J Med Chem· June 2019

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Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
Rachel Gurrell, Donal Gorman, Mark Whitlock, Adam Ogden, David S Reynolds

Neurology· April 2019

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A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain.
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, David S Reynolds

Pain· September 2018

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Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.
Angela N Duke, Zhiqiang Meng, Donna M Platt, John R Atack, Gerard R Dawson, David S Reynolds

J Pharmacol Exp Ther· July 2018

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Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA receptor positive allosteric modulator PF-06372865.
Sarah A Nickolls, Rachel Gurrell, Guido van Amerongen, Juha Kammonen, Lishuang Cao, David S Reynolds

Br J Pharmacol· February 2018

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Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.
Wendy J Winchester, Katrina Gore, Sophie Glatt, Wendy Petit, Jennifer C Gardiner, David S Reynolds

J Pharmacol Exp Ther· November 2014

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Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys.
Nina M Shinday, Eileen K Sawyer, Bradford D Fischer, Donna M Platt, Stephanie C Licata, David S Reynolds

Neuropsychopharmacology· May 2013

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Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.
Bradford D Fischer, John R Atack, Donna M Platt, David S Reynolds, Gerard R Dawson

Psychopharmacology (Berl)· May 2011

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Assessment of 'active investigation' as a potential measure of female sexual incentive motivation in a preclinical non-contact rodent model: observations with apomorphine.
Anthony B Hawcock, Toni E Dawkins, David S Reynolds

Pharmacol Biochem Behav· April 2010

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Potentiation of reflex erectile responses in the anaesthetized rat by the selective melanocortin receptor 4 agonist MB243.
Julien Allard, David S Reynolds, Nicholas J Edmunds

BJU Int· September 2008

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The value of genetic and pharmacological approaches to understanding the complexities of GABA(A) receptor subtype functions: the anxiolytic effects of benzodiazepines.
David S Reynolds

Pharmacol Biochem Behav· July 2008

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Guest editor's note.
David S Reynolds, Gerard R Dawson

Pharmacol Biochem Behav· July 2008

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Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
Rosa L Fradley, Martin R Guscott, Sharlene Bull, David J Hallett, Simon C Goodacre, David S Reynolds

J Psychopharmacol· June 2007

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The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole.
James O Groves, Martin R Guscott, David J Hallett, Thomas W Rosahl, Andrew Pike, David S Reynolds

Eur J Neurosci· July 2006

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The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
John R Atack, Andy Pike, George Marshall, Jo Stanley, Rachael Lincoln, David S Reynolds

Neuropharmacology· May 2006

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A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Richard T Lewis, Wesley P Blackaby, Timothy Blackburn, Andrew S R Jennings, Andrew Pike, David S Reynolds

J Med Chem· April 2006

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Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Simon C Goodacre, David J Hallett, Robert W Carling, José L Castro, David S Reynolds

Bioorg Med Chem Lett· March 2006

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Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Andrew S R Jennings, Richard T Lewis, Michael G N Russell, David J Hallett, Leslie J Street, David S Reynolds

Bioorg Med Chem Lett· March 2006

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Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Michael G N Russell, Robert W Carling, Leslie J Street, David J Hallett, Simon Goodacre, David S Reynolds

J Med Chem· February 2006

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
Rebecca Dias, Wayne F A Sheppard, Rosa L Fradley, Elizabeth M Garrett, Joanna L Stanley, David S Reynolds

J Neurosci· November 2005

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Effects of reinforcement schedule on facilitation of operant extinction by chlordiazepoxide.
Julian C Leslie, David Shaw, Gillian Gregg, Nichola McCormick, David S Reynolds

J Exp Anal Behav· November 2005

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STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating.
Rosa L Fradley, Gillian F O'Meara, Richard J Newman, Annie Andrieux, Didier Job, David S Reynolds

Behav Brain Res· September 2005

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