Publications by authors named "Robert W Carling"

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A Second Generation Prostanoid Receptor Antagonist Acting at Multiple Receptor Subtypes.
David F Woodward, Jenny W Wang, Clayton S Spada, Robert W Carling, Jose L Martos

ACS Pharmacol Transl Sci· December 2020

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FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.
Alessia Ligresti, Cristoforo Silvestri, Rosa Maria Vitale, Jose L Martos, Fabiana Piscitelli, Robert W Carling

ACS Chem Neurosci· January 2019

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In vivo studies validating multitargeting of prostanoid receptors for achieving superior anti-inflammatory effects.
David F Woodward, Jenny W Wang, Ming Ni, Alex Bauer, Jose L Martos, Robert W Carling

FASEB J· January 2017

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Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory activity in macrophages.
Jenny W Wang, David F Woodward, Jose L Martos, Clive L Cornell, Robert W Carling

FASEB J· January 2016

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Cellular basis for bimatoprost effects on human conventional outflow.
W Daniel Stamer, David Piwnica, Thierry Jolas, Robert W Carling, Clive L Cornell

Invest Ophthalmol Vis Sci· October 2010

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N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.
Jason M Elliott, Robert W Carling, Gary G Chicchi, James Crawforth, Peter H Hutson

Bioorg Med Chem Lett· November 2006

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N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.
Jason M Elliott, Robert W Carling, Mark Chambers, Gary G Chicchi, Peter H Hutson

Bioorg Med Chem Lett· November 2006

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2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.
Robert W Carling, Michael G N Russell, Kevin W Moore, Andrew Mitchinson, Alexander Guiblin

Bioorg Med Chem Lett· July 2006

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Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Simon C Goodacre, David J Hallett, Robert W Carling, José L Castro, David S Reynolds

Bioorg Med Chem Lett· March 2006

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Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Michael G N Russell, Robert W Carling, Leslie J Street, David J Hallett, Simon Goodacre

J Med Chem· February 2006

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7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Robert W Carling, Andrew Madin, Alec Guiblin, Michael G N Russell, Kevin W Moore

J Med Chem· November 2005

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Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
Michael G N Russell, Robert W Carling, John R Atack, Frances A Bromidge, Susan M Cook

J Med Chem· March 2005

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An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
Mark S Chambers, John R Atack, Robert W Carling, Neil Collinson, Susan M Cook

J Med Chem· November 2004

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2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.
Andrew Mitchinson, John R Atack, Peter Blurton, Robert W Carling, José L Castro

Bioorg Med Chem Lett· July 2004

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Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
Leslie J Street, Francine Sternfeld, Richard A Jelley, Austin J Reeve, Robert W Carling

J Med Chem· July 2004

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Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
Francine Sternfeld, Robert W Carling, Richard A Jelley, Tamara Ladduwahetty, Kevin J Merchant

J Med Chem· April 2004

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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
Robert W Carling, Kevin W Moore, Leslie J Street, Deborah Wild, Catherine Isted

J Med Chem· March 2004

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