Publications by authors named "Susan M Cook"

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Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Andrew Pike, Susan M Cook, Alan P Watt, Paul Scott-Stevens, Thomas W Rosahl

Biopharm Drug Dispos· September 2007

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Comparison of in vivo and ex vivo [3H]flumazenil binding assays to determine occupancy at the benzodiazepine binding site of rat brain GABAA receptors.
Jennifer Li, Rebecca L Fish, Susan M Cook, Frederick D Tattersall, John R Atack

Neuropharmacology· July 2006

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The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
John R Atack, Andy Pike, George Marshall, Jo Stanley, Rachael Lincoln, Susan M Cook

Neuropharmacology· May 2006

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Rat pharmacokinetics and pharmacodynamics of a sustained release formulation of the GABAA alpha5-selective compound L-655,708.
John R Atack, Andy Pike, Ashley Clarke, Susan M Cook, Bindi Sohal

Drug Metab Dispos· May 2006

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A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Richard T Lewis, Wesley P Blackaby, Timothy Blackburn, Andrew S R Jennings, Andrew Pike, Susan M Cook

J Med Chem· April 2006

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Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Andrew S R Jennings, Richard T Lewis, Michael G N Russell, David J Hallett, Leslie J Street, Susan M Cook

Bioorg Med Chem Lett· March 2006

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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
Philip Jones, John R Atack, Matthew P Braun, Brian P Cato, Mark S Chambers, Susan M Cook

Bioorg Med Chem Lett· February 2006

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Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Michael G N Russell, Robert W Carling, Leslie J Street, David J Hallett, Simon Goodacre, Susan M Cook

J Med Chem· February 2006

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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
John R Atack, Keith A Wafford, Spencer J Tye, Susan M Cook, Bindi Sohal

J Pharmacol Exp Ther· January 2006

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Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
Simon C Goodacre, Leslie J Street, David J Hallett, James M Crawforth, Sarah Kelly, Susan M Cook

J Med Chem· January 2006

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Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.
Luanda J Pym, Susan M Cook, Thomas Rosahl, Ruth M McKernan, John R Atack

Br J Pharmacol· November 2005

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7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Robert W Carling, Andrew Madin, Alec Guiblin, Michael G N Russell, Kevin W Moore, Susan M Cook

J Med Chem· November 2005

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
Rebecca Dias, Wayne F A Sheppard, Rosa L Fradley, Elizabeth M Garrett, Joanna L Stanley, Susan M Cook

J Neurosci· November 2005

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In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.
John R Atack, Luanda Alder, Susan M Cook, Alison J Smith, Ruth M McKernan

Neuropharmacology· August 2005

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Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
Michael G N Russell, Robert W Carling, John R Atack, Frances A Bromidge, Susan M Cook

J Med Chem· March 2005

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Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.
John R Atack, Peter H Hutson, Neil Collinson, George Marshall, Graham Bentley, Susan M Cook

Br J Pharmacol· February 2005

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An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
Mark S Chambers, John R Atack, Robert W Carling, Neil Collinson, Susan M Cook

J Med Chem· November 2004

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3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.
Helen J Szekeres, John R Atack, Mark S Chambers, Susan M Cook, Alison J Macaulay

Bioorg Med Chem Lett· June 2004

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Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.
James Crawforth, John R Atack, Susan M Cook, Karl R Gibson, Alan Nadin

Bioorg Med Chem Lett· April 2004

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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
Robert W Carling, Kevin W Moore, Leslie J Street, Deborah Wild, Catherine Isted, Susan M Cook

J Med Chem· March 2004

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