Publications by authors named "Kevin W Moore"

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Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.
David F Fiorentino, Albert Zlotnik, Paulo Vieira, Timothy R Mosmann, Maureen Howard, Kevin W Moore

J Immunol· September 2016

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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
Richard Smith, Amy Duguay, Alice Bakker, Peng Li, Jennifer Weiszmann, Kevin W Moore

PLoS One· November 2013

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Pillars article: homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990. 248: 1230-1234.
Kevin W Moore, Paulo Vieira, David F Fiorentino, Mary L Trounstine, Tariq A Khan

J Immunol· September 2012

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2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.
Robert W Carling, Michael G N Russell, Kevin W Moore, Andrew Mitchinson, Alexander Guiblin

Bioorg Med Chem Lett· July 2006

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Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.
Sherry H-Y Wei, Andrew Ming-Lum, Ying Liu, David Wallach, Christopher J Ong, Kevin W Moore

J Interferon Cytokine Res· May 2006

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Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains.
Joshua Silverman, Qiang Liu, Alice Bakker, Wayne To, Amy Duguay, Kevin W Moore

Nat Biotechnol· December 2005

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7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.
Robert W Carling, Andrew Madin, Alec Guiblin, Michael G N Russell, Kevin W Moore

J Med Chem· November 2005

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Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.
Michael G N Russell, Robert W Carling, John R Atack, Frances A Bromidge, Susan M Cook, Kevin W Moore

J Med Chem· March 2005

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2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.
Andrew Mitchinson, John R Atack, Peter Blurton, Robert W Carling, José L Castro, Kevin W Moore

Bioorg Med Chem Lett· July 2004

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Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
Leslie J Street, Francine Sternfeld, Richard A Jelley, Austin J Reeve, Robert W Carling, Kevin W Moore

J Med Chem· July 2004

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Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
Francine Sternfeld, Robert W Carling, Richard A Jelley, Tamara Ladduwahetty, Kevin J Merchant, Kevin W Moore

J Med Chem· April 2004

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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
Robert W Carling, Kevin W Moore, Leslie J Street, Deborah Wild, Catherine Isted

J Med Chem· March 2004

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Christi Parham, Madaline Chirica, Jacqueline Timans, Elena Vaisberg, Marilyn Travis, Kevin W Moore

J Immunol· June 2002

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