Publications by authors named "David Blakemore"

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Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity.
Mark E Schnute, Huixian Wu, John I Trujillo, Wei Li, David Jonathan Wasilko, David C Blakemore

J Med Chem· October 2025

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Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio, David C Blakemore

Chem Sci· October 2025

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Desulfinative Cross-Coupling as a Method to Overcome Problematic Suzuki-Miyaura Reactions of Pharmaceutically Relevant Heteroaromatic Boronates.
David C Blakemore, Andre Shavnya, Michael C Willis

ACS Med Chem Lett· August 2025

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Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule.
Mark E Schnute, Gary M Chinigo, Kentaro Futatsugi, Masaya Yamaguchi, Scott W Bagley, David C Blakemore

ACS Med Chem Lett· August 2025

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Synthesis of α-Aryl and α-Heteroaryl 4-Silyloxy Piperidines via a One-Pot Negishi Cross-Coupling Approach.
Matthew T Gill, Lucy A Tomczyk, Andres R Gomez-Angel, James D Firth, David C Blakemore

Chemistry· June 2025

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Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization.
David F Fernández, María González-Esguevillas, Sebastian Keess, Felix Schäfer, Jens Mohr, David C Blakemore

Org Lett· April 2024

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Copper-Catalyzed Synthesis of Masked (Hetero)Aryl Sulfinates.
May R Merino, Xinlan A F Cook, David C Blakemore, Ian B Moses, Neal W Sach

Org Lett· April 2024

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Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides.
Sandra E Gatarz, Oliver M Griffiths, Henrique A Esteves, Wenhua Jiao, Peter Morse, David C Blakemore

J Org Chem· February 2024

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One-Pot Synthesis of Sulfonamides from Unactivated Acids and Amines via Aromatic Decarboxylative Halosulfonylation.
P Scott Pedersen, David C Blakemore, Gary M Chinigo, Thomas Knauber, David W C MacMillan

J Am Chem Soc· October 2023

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard, David C Blakemore

RSC Med Chem· December 2022

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Reductant-Free Cross-Electrophile Synthesis of Di(hetero)arylmethanes by Palladium-Catalyzed Desulfinative C-C Coupling.
Janette McKnight, Andre Shavnya, Neal W Sach, David C Blakemore, Ian B Moses

Angew Chem Int Ed Engl· May 2022

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A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids.
Tiffany Q Chen, P Scott Pedersen, Nathan W Dow, Remi Fayad, Cory E Hauke, David C Blakemore

J Am Chem Soc· May 2022

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Decarboxylative Borylation and Cross-Coupling of (Hetero)aryl Acids Enabled by Copper Charge Transfer Catalysis.
Nathan W Dow, P Scott Pedersen, Tiffany Q Chen, David C Blakemore, Anne-Marie Dechert-Schmitt

J Am Chem Soc· April 2022

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Decarbonylative Pd-Catalyzed Suzuki Cross-Coupling for the Synthesis of Structurally Diverse Heterobiaryls.
Alejandro Cervantes-Reyes, Aaron C Smith, Gary M Chinigo, David C Blakemore, Michal Szostak

Org Lett· March 2022

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Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions.
Xinlan A F Cook, Loïc R E Pantaine, David C Blakemore, Ian B Moses, Neal W Sach

Angew Chem Int Ed Engl· October 2021

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Photoredox-Catalyzed Dehydrogenative Csp-Csp Cross-Coupling of Alkylarenes to Aldehydes in Flow.
Oliver M Griffiths, Henrique A Esteves, Yiding Chen, Karin Sowa, Oliver S May, David C Blakemore

J Org Chem· October 2021

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Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor.
Brendan Kelly, Scott A Hollingsworth, David C Blakemore, Robert M Owen, R Ian Storer

J Chem Inf Model· July 2021

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Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins.
Yiding Chen, Nicole McNamara, Oliver May, Thanigaimalai Pillaiyar, David C Blakemore

Org Lett· August 2020

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Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling.
Robert Szpera, Patrick G Isenegger, Maxime Ghosez, Natan J W Straathof, Rosa Cookson, David C Blakemore

Org Lett· August 2020

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe, David C Blakemore

Chemistry· July 2020

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A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow.
Yiding Chen, Oliver May, David C Blakemore, Steven V Ley

Org Lett· August 2019

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Design and Identification of a Novel, Functionally Subtype Selective GABA Positive Allosteric Modulator (PF-06372865).
Robert M Owen, David Blakemore, Lishuang Cao, Neil Flanagan, Rebecca Fish

J Med Chem· June 2019

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The discovery and optimization of benzimidazoles as selective Na1.8 blockers for the treatment of pain.
Alan D Brown, Sharan K Bagal, Paul Blackwell, David C Blakemore, Bruce Brown

Bioorg Med Chem· January 2019

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Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow.
Yiding Chen, Marco Leonardi, Paul Dingwall, Ricardo Labes, Patrick Pasau, David C Blakemore

J Org Chem· December 2018

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Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions.
Tim Markovic, Philip R D Murray, Benjamin N Rocke, Andre Shavnya, David C Blakemore

J Am Chem Soc· November 2018

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