Publications by authors named "Thomas D Downes"

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Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio

Chem Sci· October 2025

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Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.
Jack R Davison, Michalis Hadjithomas, Stuart P Romeril, Yoon Jong Choi, Keith W Bentley, Thomas D Downes

J Med Chem· August 2024

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, Thomas D Downes

Nat Commun· October 2020

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe

Chemistry· July 2020

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