Publications by authors named "James D Firth"

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Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio

Chem Sci· October 2025

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Modular Synthetic Platform for the Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery.
Andres R Gomez-Angel, Hanna F Klein, Stephen Y Yao, James R Donald, James D Firth

J Am Chem Soc· August 2025

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Synthesis of α-Aryl and α-Heteroaryl 4-Silyloxy Piperidines via a One-Pot Negishi Cross-Coupling Approach.
Matthew T Gill, Lucy A Tomczyk, Andres R Gomez-Angel, James D Firth, David C Blakemore

Chemistry· June 2025

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Deciphering complexity in Pd-catalyzed cross-couplings.
George E Clarke, James D Firth, Lyndsay A Ledingham, Chris S Horbaczewskyj, Richard A Bourne

Nat Commun· May 2024

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α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.
Nico Seling, Masakazu Atobe, Kevin Kasten, James D Firth, Peter B Karadakov

Angew Chem Int Ed Engl· January 2024

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard

RSC Med Chem· December 2022

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Light- and Manganese-Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time-Scale Revealed by Time-Resolved Spectroscopic Analysis.
James D Firth, L Anders Hammarback, Thomas J Burden, Jonathan B Eastwood, James R Donald

Chemistry· February 2021

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Fragment-derived modulators of an industrial β-glucosidase.
Eleni Makraki, John F Darby, Marta G Carneiro, James D Firth, Alex Heyam

Biochem J· November 2020

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, James D Firth

Nat Commun· October 2020

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A Need for Caution in the Preparation and Application of Synthetically Versatile Aryl Diazonium Tetrafluoroborate Salts.
James D Firth, Ian J S Fairlamb

Org Lett· September 2020

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe, James D Firth

Chemistry· July 2020

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Gram-Scale Synthesis of the (-)-Sparteine Surrogate and (-)-Sparteine.
James D Firth, Steven J Canipa, Leigh Ferris, Peter O'Brien

Angew Chem Int Ed Engl· January 2018

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Increase of enzyme activity through specific covalent modification with fragments.
John F Darby, Masakazu Atobe, James D Firth, Paul Bond, Gideon J Davies

Chem Sci· November 2017

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General Procedures for the Lithiation/Trapping of N-Boc Piperazines.
James D Firth, Peter O'Brien, Leigh Ferris

J Org Chem· July 2017

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A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds.
James D Firth, Philip G E Craven, Matthew Lilburn, Axel Pahl, Stephen P Marsden

Chem Commun (Camb)· July 2016

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Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent.
James D Firth, Peter O'Brien, Leigh Ferris

J Am Chem Soc· January 2016

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Revisiting the sparteine surrogate: development of a resolution route to the (-)-sparteine surrogate.
James D Firth, Peter O'Brien, Leigh Ferris

Org Biomol Chem· December 2014

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Lipopolysaccharide induces a stromal-epithelial signalling axis in a rat model of chronic periodontitis.
James D Firth, Daisuke Ekuni, Koichiro Irie, Takaaki Tomofuji, Manabu Morita

J Clin Periodontol· January 2013

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An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters.
Nadeem S Sheikh, Daniele Leonori, Graeme Barker, James D Firth, Kevin R Campos

J Am Chem Soc· March 2012

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Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model.
Daisuke Ekuni, James D Firth, Tarun Nayer, Takaaki Tomofuji, Toshihiro Sanbe

Am J Pathol· October 2009

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An in vitro analysis of mechanical wounding-induced ligand-independent KGFR activation.
Min Li, James D Firth, Edward E Putnins

J Dermatol Sci· March 2009

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Mechanical induction of an epithelial cell chymase associated with wound edge migration.
James D Firth, Veli-Jukka Uitto, Edward E Putnins

J Biol Chem· December 2008

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RNA integrity and in situ RT-PCR in dento-alveolar tissues after microwave accelerated demineralisation.
Daisuke Ekuni, James D Firth, Edward E Putnins

Arch Oral Biol· February 2006

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Diastereoselective synthesis of 4-hydroxypiperidin-2-ones via Cu(I)-catalyzed reductive aldol cyclization.
Hon Wai Lam, Gordon J Murray, James D Firth

Org Lett· December 2005

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Keratinocyte growth factor-1 expression in healthy and diseased human periodontal tissues.
Min Li, James D Firth, Edward E Putnins

J Periodontal Res· April 2005

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