Publications by authors named "Roderick E Hubbard"

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D
Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio, Roderick E Hubbard

Chem Sci· October 2025

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P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.
Martin J Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A Maunders, Roderick E Hubbard

Cell Rep· October 2025

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Editorial overview - New Concepts in Drug Discovery (2025).
Philip C Biggin, Roderick E Hubbard

Curr Opin Struct Biol· August 2025

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Structure-Atropisomer Stability Relationship in Selective MCL-1 Inhibitors.
Szabolcs Sipos, Barbara Balazs, Tamas Gati, Márton Csékei, Mihály Kováacs, Roderick E Hubbard

ChemMedChem· May 2025

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Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
Attila Vasas, Lisa Ivanschitz, Balázs Molnár, Árpád Kiss, Lisa Baker, Roderick E Hubbard

J Med Chem· November 2024

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Identification of a Novel Subtype-Selective α-Adrenoceptor Antagonist.
Alaa Abdul-Ridha, Lazarus A de Zhang, Ashenafi Haileyesus Betrie, Mattia Deluigi, Tasneem M Vaid, Roderick E Hubbard

ACS Chem Neurosci· February 2024

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Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors.
Edward A FitzGerald, Darius Vagrys, Giulia Opassi, Hanna F Klein, David J Hamilton, Roderick E Hubbard

SLAS Discov· January 2024

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A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Naoki Kuki, David L Walmsley, Kazuo Kanai, Sho Takechi, Masao Yoshida, Roderick E Hubbard

RSC Med Chem· December 2023

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Fragment Merging Using a Graph Database Samples Different Catalogue Space than Similarity Search.
Stephanie Wills, Ruben Sanchez-Garcia, Tim Dudgeon, Stephen D Roughley, Andy Merritt, Roderick E Hubbard

J Chem Inf Model· June 2023

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard

RSC Med Chem· December 2022

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PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
Huiyong Ma, James B Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen, Roderick E Hubbard

RSC Med Chem· November 2022

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P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells.
Elizabeth Hampson, Elpida Tsonou, Martin J Baker, David C Hornigold, Roderick E Hubbard

Cells· September 2021

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The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Szabolcs Sipos, Balázs Bálint, Zoltán B Szabó, Levente Ondi, Márton Csékei, Roderick E Hubbard

ACS Omega· August 2021

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Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
David Lee Walmsley, James B Murray, Pawel Dokurno, Andrew J Massey, Karen Benwell, Roderick E Hubbard

J Med Chem· July 2021

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Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
Csaba Weber, Melinda Sipos, Attila Paczal, Balazs Balint, Vilibald Kun, Roderick E Hubbard

J Med Chem· May 2021

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Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Yousuke Yamada, Hajime Takashima, David Lee Walmsley, Fumihito Ushiyama, Yohei Matsuda, Roderick E Hubbard

J Med Chem· December 2020

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Fragment-derived modulators of an industrial β-glucosidase.
Eleni Makraki, John F Darby, Marta G Carneiro, James D Firth, Alex Heyam, Roderick E Hubbard

Biochem J· November 2020

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Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor.
Zoltan Szlavik, Marton Csekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Roderick E Hubbard

J Med Chem· November 2020

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H, C, N backbone and IVL methyl group resonance assignment of the fungal β-glucosidase from Trichoderma reesei.
Eleni Makraki, Marta G Carneiro, Alex Heyam, A B Eiso, Gregg Siegal, Roderick E Hubbard

Biomol NMR Assign· October 2020

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Correction to: H, C, N backbone and IVL methyl group resonance assignment of the fungal β-glucosidase from Trichoderma reesei.
Eleni Makraki, Marta G Carneiro, Alex Heyam, Eiso Ab, Gregg Siegal, Roderick E Hubbard

Biomol NMR Assign· October 2020

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Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.
Lisa M Baker, Anthony Aimon, James B Murray, Allan E Surgenor, Natalia Matassova, Roderick E Hubbard

Commun Chem· September 2020

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard

Chemistry· July 2020

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Exploring IDP-Ligand Interactions: tau K18 as A Test Case.
Darius Vagrys, James Davidson, Ijen Chen, Roderick E Hubbard, Ben Davis

Int J Mol Sci· July 2020

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Water Networks Can Determine the Affinity of Ligand Binding to Proteins.
John F Darby, Adam P Hopkins, Seishi Shimizu, Shirley M Roberts, James A Brannigan, Roderick E Hubbard

J Am Chem Soc· October 2019

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Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
James B Murray, James Davidson, Ijen Chen, Ben Davis, Pawel Dokurno, Roderick E Hubbard

ACS Omega· May 2019

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