Publications by authors named "James B Murray"

Claim this Profile
S
Structure-Atropisomer Stability Relationship in Selective MCL-1 Inhibitors.
Szabolcs Sipos, Barbara Balazs, Tamas Gati, Márton Csékei, Mihály Kováacs, James B Murray

ChemMedChem· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
Attila Vasas, Lisa Ivanschitz, Balázs Molnár, Árpád Kiss, Lisa Baker, James B Murray

J Med Chem· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Naoki Kuki, David L Walmsley, Kazuo Kanai, Sho Takechi, Masao Yoshida, James B Murray

RSC Med Chem· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PAC-FragmentDEL - photoactivated covalent capture of DNA-encoded fragments for hit discovery.
Huiyong Ma, James B Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen

RSC Med Chem· November 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Szabolcs Sipos, Balázs Bálint, Zoltán B Szabó, Levente Ondi, Márton Csékei, James B Murray

ACS Omega· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
David Lee Walmsley, James B Murray, Pawel Dokurno, Andrew J Massey, Karen Benwell

J Med Chem· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.
Lisa M Baker, Anthony Aimon, James B Murray, Allan E Surgenor, Natalia Matassova

Commun Chem· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
James B Murray, James Davidson, Ijen Chen, Ben Davis, Pawel Dokurno

ACS Omega· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department.
Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, James B Murray

BMC Med· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
Douglas S Williamson, Garrick P Smith, Pamela Acheson-Dossang, Simon T Bedford, Victoria Chell, James B Murray

J Med Chem· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
Paul A Brough, Lisa Baker, Simon Bedford, Kirsten Brown, Seema Chavda, James B Murray

J Med Chem· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products.
James B Murray, Stephen D Roughley, Natalia Matassova, Paul A Brough

J Med Chem· April 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Shielded hydrogen bonds as structural determinants of binding kinetics: application in drug design.
Peter Schmidtke, F Javier Luque, James B Murray, Xavier Barril

J Am Chem Soc· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Experiences in fragment-based lead discovery.
Roderick E Hubbard, James B Murray

Methods Enzymol· June 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Alba T Macias, Douglas S Williamson, Nicola Allen, Jenifer Borgognoni, Alexandra Clay, James B Murray

J Med Chem· June 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
Andrew Potter, Victoria Oldfield, Claire Nunns, Christophe Fromont, Stuart Ray, James B Murray

Bioorg Med Chem Lett· November 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
Andrew J Massey, Douglas S Williamson, Helen Browne, James B Murray, Pawel Dokurno

Cancer Chemother Pharmacol· August 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
Andrew J Potter, Stuart Ray, Louisa Gueritz, Claire L Nunns, Christopher J Bryant, James B Murray

Bioorg Med Chem Lett· January 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
Douglas S Williamson, Jenifer Borgognoni, Alexandra Clay, Zoe Daniels, Pawel Dokurno, James B Murray

J Med Chem· March 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Christine M Richardson, Claire L Nunns, Douglas S Williamson, Martin J Parratt, Pawel Dokurno, James B Murray

Bioorg Med Chem Lett· July 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.
Jiro Kondo, Boris François, Rupert J M Russell, James B Murray, Eric Westhof

Biochimie· August 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Christine M Richardson, Douglas S Williamson, Martin J Parratt, Jenifer Borgognoni, Andrew D Cansfield, James B Murray

Bioorg Med Chem Lett· March 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.
James B Murray, Samy O Meroueh, Rupert J M Russell, Georg Lentzen, Jalal Haddad

Chem Biol· February 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Boris François, Rupert J M Russell, James B Murray, Fareed Aboul-ela, Benoît Masquida

Nucleic Acids Res· October 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Douglas S Williamson, Martin J Parratt, Justin F Bower, Jonathan D Moore, Christine M Richardson, James B Murray

Bioorg Med Chem Lett· February 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis