Publications by authors named "Arthur D Clark"

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Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
Kalyan Das, Joseph D Bauman, Angela S Rim, Chhaya Dharia, Arthur D Clark

J Med Chem· April 2011

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Structural basis of HIV-1 resistance to AZT by excision.
Xiongying Tu, Kalyan Das, Qianwei Han, Joseph D Bauman, Arthur D Clark

Nat Struct Mol Biol· October 2010

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Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
Kalyan Das, Rajiv P Bandwar, Kirsten L White, Joy Y Feng, Stefan G Sarafianos, Arthur D Clark

J Biol Chem· December 2009

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Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Daniel M Himmel, Karen A Maegley, Tom A Pauly, Joseph D Bauman, Kalyan Das, Arthur D Clark

Structure· December 2009

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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Joseph D Bauman, Kalyan Das, William C Ho, Mukta Baweja, Daniel M Himmel, Arthur D Clark

Nucleic Acids Res· September 2008

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.
Kalyan Das, Joseph D Bauman, Arthur D Clark, Yulia V Frenkel, Paul J Lewi

Proc Natl Acad Sci U S A· February 2008

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Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.
Kalyan Das, Stefan G Sarafianos, Arthur D Clark, Paul L Boyer, Stephen H Hughes

J Mol Biol· January 2007

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HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Daniel M Himmel, Stefan G Sarafianos, Sanjeewa Dharmasena, Mohammed M Hossain, Kessler McCoy-Simandle, Arthur D Clark, Patrick K Clark

ACS Chem Biol· December 2006

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Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Daniel M Himmel, Kalyan Das, Arthur D Clark, Stephen H Hughes, Abdellah Benjahad

J Med Chem· December 2005

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Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Steven Tuske, Stefan G Sarafianos, Xinyue Wang, Brian Hudson, Elena Sineva, Arthur D Clark

Cell· August 2005

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Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
Yulia Volovik Frenkel, Arthur D Clark, Kalyan Das, Yuh-Hwa Wang, Paul J Lewi

J Med Chem· March 2005

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Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
Steve Tuske, Stefan G Sarafianos, Arthur D Clark, Jianping Ding, Lisa K Naeger, Patrick Clark

Nat Struct Mol Biol· May 2004

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Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
Kalyan Das, Arthur D Clark, Paul J Lewi, Jan Heeres, Marc R De Jonge, Patrick Clark

J Med Chem· May 2004

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Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.
Kalyan Das, Gary H Butler, Victoria Kwiatkowski, Arthur D Clark, Prem Yadav

Structure· April 2004

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Trapping HIV-1 reverse transcriptase before and after translocation on DNA.
Stefan G Sarafianos, Arthur D Clark, Steve Tuske, Christopher J Squire, Kalyan Das

J Biol Chem· May 2003

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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.
Stefan G Sarafianos, Arthur D Clark, Kalyan Das, Steve Tuske, Jens J Birktoft

EMBO J· December 2002

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