Publications by authors named "Asaf Rotem"

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A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma.
William Zhao, Thinh T Nguyen, Atharva Bhagwat, Akhil Kumar, Bruno Giotti, Asaf Rotem

Nat Cancer· November 2025

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Cambridge Neoadjuvant Cancer of the Prostate (CANCAP03): A Window Study into the Effects of Olaparib ± Degarelix in Primary Prostate Cancer.
Harveer Dev, Mark Linch, Krishna Narahari, Toby Milne-Clark, Melissa Cheung, Asaf Rotem

Clin Cancer Res· June 2025

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Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma.
Kevin Bi, Meng Xiao He, Ziad Bakouny, Abhay Kanodia, Sara Napolitano, Asaf Rotem

Cancer Cell· June 2025

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Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.
Johanna Klughammer, Daniel L Abravanel, Åsa Segerstolpe, Timothy R Blosser, Yury Goltsev, Asaf Rotem

Nat Med· May 2025

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A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.
Johanna Klughammer, Daniel L Abravanel, Åsa Segerstolpe, Timothy R Blosser, Yury Goltsev, Asaf Rotem

Nat Med· November 2024

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A cellular and spatial atlas of -associated tissue remodeling in lung adenocarcinoma.
William Zhao, Benjamin Kepecs, Navin R Mahadevan, Asa Segerstolpe, Jason L Weirather, Asaf Rotem

bioRxiv· February 2024

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A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity.
Anand G Patel, Orr Ashenberg, Natalie B Collins, Åsa Segerstolpe, Sizun Jiang, Asaf Rotem

bioRxiv· January 2024

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Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.
Samantha E Hoffman, Todd W Dowrey, Carlos Villacorta Martin, Kevin Bi, Breanna Titchen, Asaf Rotem

Sci Adv· September 2023

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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Srivatsan Raghavan, Peter S Winter, Andrew W Navia, Hannah L Williams, Alan DenAdel, Asaf Rotem

Cell· December 2021

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Spatially organized multicellular immune hubs in human colorectal cancer.
Karin Pelka, Matan Hofree, Jonathan H Chen, Siranush Sarkizova, Joshua D Pirl, Asaf Rotem

Cell· September 2021

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Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma.
Kevin Bi, Meng Xiao He, Ziad Bakouny, Abhay Kanodia, Sara Napolitano, Asaf Rotem

Cancer Cell· May 2021

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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion.
Chris J Frangieh, Johannes C Melms, Pratiksha I Thakore, Kathryn R Geiger-Schuller, Patricia Ho, Asaf Rotem

Nat Genet· March 2021

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Transcriptional mediators of treatment resistance in lethal prostate cancer.
Meng Xiao He, Michael S Cuoco, Jett Crowdis, Alice Bosma-Moody, Zhenwei Zhang, Asaf Rotem

Nat Med· March 2021

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A single-cell landscape of high-grade serous ovarian cancer.
Benjamin Izar, Itay Tirosh, Elizabeth H Stover, Isaac Wakiro, Michael S Cuoco, Asaf Rotem

Nat Med· August 2020

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Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.
Michal Slyper, Caroline B M Porter, Orr Ashenberg, Julia Waldman, Eugene Drokhlyansky, Asaf Rotem

Nat Med· August 2020

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A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.
Michal Slyper, Caroline B M Porter, Orr Ashenberg, Julia Waldman, Eugene Drokhlyansky, Asaf Rotem

Nat Med· May 2020

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Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair-Deficient Colorectal Cancer.
Carino Gurjao, David Liu, Matan Hofree, Saud H AlDubayan, Isaac Wakiro, Asaf Rotem

Cancer Immunol Res· August 2019

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Livnat Jerby-Arnon, Parin Shah, Michael S Cuoco, Christopher Rodman, Mei-Ju Su, Asaf Rotem

Cell· November 2018

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Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.
Zhe Ji, Lizhi He, Asaf Rotem, Andreas Janzer, Christine S Cheng

Nat Commun· May 2018

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Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.
Russell W Jenkins, Amir R Aref, Patrick H Lizotte, Elena Ivanova, Susanna Stinson, Asaf Rotem

Cancer Discov· February 2018

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Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.
Courtney K JnBaptiste, Allan M Gurtan, Kevin K Thai, Victoria Lu, Arjun Bhutkar, Asaf Rotem

Genes Dev· May 2017

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Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.
Courtney K JnBaptiste, Allan M Gurtan, Kevin K Thai, Victoria Lu, Arjun Bhutkar, Asaf Rotem

Genes Dev· April 2017

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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
Mohammad Fallahi-Sichani, Verena Becker, Benjamin Izar, Gregory J Baker, Jia-Ren Lin, Asaf Rotem

Mol Syst Biol· January 2017

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GILA, a Replacement for the Soft-Agar Assay that Permits High-Throughput Drug and Genetic Screens for Cellular Transformation.
Benjamin Izar, Asaf Rotem

Curr Protoc Mol Biol· October 2016

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, Sanjay M Prakadan, Marc H Wadsworth, Daniel Treacy, Asaf Rotem

Science· April 2016

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