Publications by authors named "Assumpcio Bosch"

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Targeting Amyotrophic Lateral Sclerosis with Gene Therapy: From Silencing Genes to Enhancing Neuroprotection.
Sergi Verdés, Xavier Navarro, Assumpció Bosch

Hum Gene Ther· September 2025

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Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience.
Joan Roig-Soriano, Ángel Edo, Sergi Verdés, Carlos Martín-Alonso, Cristina Sánchez-de-Diego, Assumpció Bosch

Mol Ther· August 2025

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Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience.
Joan Roig-Soriano, Ángel Edo, Sergi Verdés, Carlos Martín-Alonso, Cristina Sánchez-de-Diego, Assumpció Bosch

Mol Ther· April 2025

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Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts.
Alejandro Brao, Ángela Sánchez, Irina Rodríguez, Javier Del Rey, Silvia Lope-Piedrafita, Assumpció Bosch

Mol Ther· April 2025

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HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease.
Jon Esandi, Pedro Renault, Maria Dolores Capilla-López, Rebeca Blanch, Ángel Edo, Assumpció Bosch

Biomed Pharmacother· February 2025

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An and efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs.
Vidyullatha Vasireddy, Casey A Maguire, David W Anderson, Carrie Ng, Yi Gong, Assumpció Bosch

Mol Ther Methods Clin Dev· December 2024

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Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles.
María Bunuales, Angeles Garduno, Miguel Chillon, Assumpció Bosch, Manuela Gonzalez-Aparicio

Gene Ther· September 2024

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Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy.
Alexia Kagiava, Christos Karaiskos, George Lapathitis, Amanda Heslegrave, Irene Sargiannidou, Assumpció Bosch

Mol Ther Methods Clin Dev· September 2023

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Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure.
Joan Roig-Soriano, Cristina Sánchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdés, Carmela R Abraham, Assumpció Bosch

Sci Rep· March 2023

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Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis.
Ángel Edo, Laura Calvo-Barreiro, Herena Eixarch, Assumpció Bosch, Miguel Chillón

Neurotherapeutics· September 2022

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Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice.
Marc Leal-Julià, Jorge J Vilches, Andrea Onieva, Sergi Verdés, Ángela Sánchez, Assumpció Bosch

Mol Metab· January 2022

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A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy.
Tammi Arbel Rubinstein, Inbal Reuveni, Arkadi Hesin, Anat Klein-Goldberg, Hannes Olauson, Assumpció Bosch

Cancers (Basel)· December 2021

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Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1 ALS Mice.
Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Sergi Verdés, Belén García-Lareu, Neus Hernández, Assumpció Bosch

Front Neurol· September 2021

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GRP78 Overexpression Triggers PINK1-IPR-Mediated Neuroprotective Mitophagy.
Tatiana Leiva-Rodríguez, David Romeo-Guitart, Mireia Herrando-Grabulosa, Pau Muñoz-Guardiola, Miriam Polo, Assumpció Bosch

Biomedicines· August 2021

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Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis.
Guillem Mòdol-Caballero, Belén García-Lareu, Mireia Herrando-Grabulosa, Sergi Verdés, Rubén López-Vales, Assumpció Bosch

Neurotherapeutics· April 2021

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Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy.
Assumpció Bosch, Raúl Estévez

Front Cell Neurosci· January 2021

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Cerebellar Astrocyte Transduction as Gene Therapy for Megalencephalic Leukoencephalopathy.
Angela Sánchez, Belén García-Lareu, Meritxell Puig, Esther Prat, Jesús Ruberte, Assumpció Bosch

Neurotherapeutics· October 2020

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Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis.
Guillem Mòdol-Caballero, Belén García-Lareu, Sergi Verdés, Lorena Ariza, Irene Sánchez-Brualla, Assumpció Bosch

Neurotherapeutics· July 2020

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Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1 ALS mice.
Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Belén García-Lareu, Neus Solanes, Sergi Verdés, Assumpció Bosch

Neurobiol Dis· April 2020

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Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis.
Inmaculada Lopez-Font, Aitana Sogorb-Esteve, Míriam Javier-Torrent, Gunnar Brinkmalm, Mireia Herrando-Grabulosa, Assumpció Bosch

Neurobiol Dis· April 2019

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Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Neus Bayó-Puxan, Ana Paula Terrasso, Sophie Creyssels, Daniel Simão, Christina Begon-Pescia, Assumpció Bosch

Sci Rep· November 2018

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ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons.
Tatiana Leiva-Rodríguez, David Romeo-Guitart, Sara Marmolejo-Martínez-Artesero, Mireia Herrando-Grabulosa, Assumpció Bosch

Cell Death Dis· May 2018

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Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence.
David Romeo-Guitart, Joaquim Forés, Mireia Herrando-Grabulosa, Raquel Valls, Tatiana Leiva-Rodríguez, Assumpció Bosch

Sci Rep· January 2018

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Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.
Marta Miralles, Herena Eixarch, Marcos Tejero, Carme Costa, Keiji Hirota, Assumpció Bosch

Neurotherapeutics· October 2017

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Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1(G93A) ALS mice and after partial muscle denervation.
Renzo Mancuso, Anna Martínez-Muriana, Tatiana Leiva, David Gregorio, Lorena Ariza, Assumpció Bosch

Neurobiol Dis· November 2016

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